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Sensitization tumour cell medicament and uses thereof

A technology of tumor cells and anti-tumor drugs, which is applied in the application field of sensitizing tumor cell agents, that is, lead compounds, and anti-tumor. It can solve the problems of drug resistance of tumor cells, reduction of tumor chemotherapy efficacy, and enhancement of cell viability.

Inactive Publication Date: 2008-05-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the most important and common one is P-gp, also known as typical MDR, which is a protein widely present on the cell membrane of various tumor cells, and is responsible for pumping intracellular drugs out of the cell, thereby causing tumor cell death. Multidrug resistance reduces efficacy of cancer chemotherapy
On the other hand, it may be due to the increase in the expression or activity of some drug-resistant proteins, which leads to the enhancement of the viability of the cells themselves, so that the tumor cells develop drug resistance.

Method used

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  • Sensitization tumour cell medicament and uses thereof
  • Sensitization tumour cell medicament and uses thereof
  • Sensitization tumour cell medicament and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] (1) Materials

[0016] 1. Instruments: biological safety cabinet (Suzhou Antai Air Technology Co., Ltd.), cell culture incubator (Thermo Forma), optical microscope, -80 ℃ ultra-low temperature refrigerator (Forma Scientific), micro-low temperature desktop centrifuge (Thermo Electron Corporation), desktop freezer High-speed centrifuge (SORVALL Heraeus), silent mixer, full-wavelength microplate reader (ThermoElectron Corporation), thermal cycler (BIO-RAD), 7500 real-time fluorescent quantitative PCR instrument (ABI), microcomputer precision acidity meter, electronic Analytical balance (Sartorius), constant temperature metal bath (Shanghai Blue Leopard Experimental Instrument Co., Ltd.), EPS-300 electrophoresis instrument (Tianneng), electrophoresis tank (Tianneng), VE-186 transfer electrophoresis tank (Tianneng), shaking table.

[0017] 2. Main reagents:

[0018] (1) Fetal bovine serum (FBS) (GIBCO)

[0019] (2) DMEM medium (GIBCO)

[0020] (3) MEM medium (GIBCO)

[0...

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Abstract

The invention relates to a sensitizing tumor cell medicament and the application, the sensitizing tumor cell medicament is a small molecule compound of coralyne chloride ZDAK01 which has the effective inhibition effect on Nrf2, and the invention can be combined with anti-cancer drugs to be used in the development and preparation of anti-cancer drugs. The small molecule compound of coralyne chloride ZDAK01 has the following structural formula.

Description

technical field [0001] The invention belongs to medical biotechnology and relates to the research and development of new drugs, specifically a lead compound ZDAK01 (coralyne chloride), which is a drug for sensitizing tumor cells, and its application in anti-tumor. Background technique [0002] 90% of patients who died of tumors are related to the drug resistance of tumor cells, especially multidrug resistance (MDR), which refers to the resistance of tumor cells to an anti-tumor drug and the Other antineoplastic drugs with different structures and mechanisms of action also produce cross-resistance. Among the factors that lead to multidrug resistance, the main factors related to cell membranes are P-glycoprotein (P-gp), multidrug resistance-related protein (MRP) and lung multidrug resistance-related protein (LRP) etc., and the main factors related to the cytoplasm are the inhibitor of apoptosis proteins (I-APs). Topoisomerase II, protein kinase C and glutathione redox system...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P35/00
Inventor 唐修文
Owner ZHEJIANG UNIV
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