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Andrographis lactone self-emulsification capsule of antibacterial antiphlogistic
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An andrographolide, antibacterial and anti-inflammatory technology, applied in capsule delivery, antibacterial drugs, antiviral agents, etc., can solve the problem of high requirements for production equipment, reduce equipment requirements, and improve the effect of bioavailability
Inactive Publication Date: 2010-11-17
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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Problems solved by technology
The self-emulsifying capsule contains a large amount of fluid components, such as ethanol, propylene glycol, oil, etc., so it can only be prepared into soft capsules, or injected into hard capsules and must be sealed, which requires high production equipment
Method used
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example 1
[0050] Weigh 100g of andrographolide, 240g of Tween 80, and 65g of soybean oil, mix them evenly at room temperature, then add 495g of PEG-6000, heat to 60-70°C, melt and stir evenly, pack them into No. 1 empty capsules, cool and solidify , made into 3000 self-emulsifying capsules, each 0.3g, containing 0.03g of andrographolide. Dosage: Take orally, 1-2 capsules each time, 3 times per eye.
example 2
[0052] Weigh 100g of andrographolide, 240g of Tween 80, and 96g of soybean oil, mix them evenly at room temperature, then add 464g of PEG-6000, heat to 60-70°C, melt and stir evenly, pack them into No. 1 empty capsules, cool and solidify , made into 3000 self-emulsifying capsules, each 0.3g, containing 0.03g of andrographolide.
[0053] Dosage: Take orally, 1-2 capsules each time, 3 times a day.
example 3
[0055] Weigh 100g of andrographolide, 200g of Tween 80, and 32g of soybean oil, mix them evenly at room temperature, then add 568g of PEG-6000, heat to 60-70°C, melt and stir evenly, pack them into No. 1 empty capsules, cool and solidify , made into 3000 self-emulsifying capsules, each 0.3g, containing 0.03g of andrographolide.
[0056] Dosage: Take orally, 1-2 capsules each time, 3 times a day.
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Abstract
The invention provides an andrographolide self-emulsifying capsule with the function of antisepsis and anti-inflammation. The capsule is prepared by the method that 5 percent to 30 percent of the andrographolide, 1 percent to 20 percent of vegetable oil and 1 percent to 40 percent of emulsifier are evenly mixed in the normal temperature; and then 20 percent to 90 percent of solid dispersion forming agent is added into the mixture; then the mixture is heated to reach 60 to 70 DEG C so that the mixture can be mixed evenly by thermal thawing; the mixture is encapsulated into an empty capsule; finally, the encapsulated mixture is cooled. Wherein, the vegetable oil is soybean oil or tea oil; the emulsifier is tween-80, soybean phospholipid or poloxamer 188 ; and the solid dispersion forming agent is polyethylene glycol whose molecular weight is 4000 to 20000.
Description
technical field [0001] The invention relates to a medical preparation, in particular to a capsule with andrographolide as an active ingredient. Background technique [0002] Andrographis paniculata (Burm.f.) Nees, also known as Lavender, Yijianxi, etc., is a plant of the Acanthaceae family. It is native to tropical regions such as the Philippines, India, Sri Lanka, and Thailand. It was introduced by overseas Chinese in the 1950s. It was cultivated in Guangdong and Fujian in my country, and then moved north to Shaanxi, Beijing, Sichuan and other places. Andrographis paniculata is a commonly used clinical medicine and one of the first-choice antiviral drugs. The whole herb is used as medicine, which has the effects of clearing away heat and detoxification, reducing inflammation, reducing swelling and relieving pain, and has anti-inflammatory, antibacterial, antiviral, anticancer, and anticardiovascular diseases. . Currently, there are Andrographolide Tablets, Andrographis Inj...
Claims
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