Medicine for treating senile dementia and preparing method thereof

A technology for senile dementia and medicine, applied in the field of senile dementia medicine and its preparation, can solve the problems of less research on the mechanism of Aβ clearance and degradation, and difficulty in revealing the characteristics of traditional Chinese medicine compound.

Active Publication Date: 2008-07-30
田金洲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Second, there are many observations on reducing the area and quantity of Aβ deposition, but less research on the mechanism of Aβ clearance and degradation
Third, more attention has been paid to the neurotoxicity of Aβ, but less research has been done on the repair of neurons after injury and the promotion of neuron regeneration
Fourth, the research model of chemical drug effects of "one drug, one target" is difficult to reveal the characteristics of the effect of "one drug, multiple targets" of traditional Chinese medicine compound

Method used

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  • Medicine for treating senile dementia and preparing method thereof
  • Medicine for treating senile dementia and preparing method thereof
  • Medicine for treating senile dementia and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0051] 10 parts of ginseng stems and leaves, 8 parts of polygala,

[0052] Epimedium 10 parts, turmeric 8 parts.

[0053] Stems and leaves of ginseng, polygala, epimedium and turmeric (purchased from Beijing Tongrentang Pharmaceutical Co., Ltd.), parts by weight are as above; 80% ethanol, 95% ethanol (analytical grade, Beijing Chemical Plant).

[0054] Preparation:

[0055] Add about 8-10 times the volume of water to the raw materials of traditional Chinese medicine, immerse the medicinal materials, soak for a suitable time (about 10 hours), heat to boil, decoct the medicinal liquid, and extract continuously for 3 times, the first time is 2 hours, the second time 1.5 hours, 1 hour for the third time, try to make the drug leaching out, combine the water extracts, concentrate on low heat, concentrate to a thick paste with a density of 1.03-1.10 (50°C), cool and stand for a period of time (about 4 hours), Let it cool, let it stand for about 24 hours, filter, condense into an ex...

preparation Embodiment 2

[0057] 10 parts of ginseng stems and leaves, 8 parts of polygala,

[0058] 10 parts of epimedium, 8 parts of turmeric

[0059] 8 parts of Danshen, 8 parts of Shichangpu,

[0060] Angelica 8 parts, Cistanche 8 parts.

[0061] The preparation method is the same as in Example 1, except that the above-mentioned parts by weight of salvia miltiorrhiza, calamus, angelica and cistanche are added to the raw materials.

preparation Embodiment 3

[0063] 1 part of ginseng stem and leaf, 1 part of polygala,

[0064] Epimedium 1 part, turmeric 1 part.

[0065] The preparation method is the same as that of Example 1, except that the proportions of the parts by weight of the raw materials are different.

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PUM

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Abstract

The invention discloses a new compound medicament of the effective ingredients of traditional Chinese medicines used for curing senile dementia. The drug ingredients is mainly used for tonifying the kidney, tonifying qi, removing heat-phlegm and activating blood; the invention is prepared by the extraction of the effective ingredients which adopt epimedium, ginseng leaves and stems, roots of polygala tenuifolia and radix curcumae as raw materials, and has obvious therapeutic effects to the senile dementia, especially for Alzheimer' s disease.

Description

technical field [0001] The invention relates to a medicine for treating senile dementia and a preparation method thereof, more specifically, a medicine for treating senile dementia mainly caused by Alzheimer's disease prepared from Chinese herbal medicine and a preparation method thereof. Background technique [0002] Senile dementia includes types such as Alzheimer's disease (AD) and vascular dementia (VaD). So far, there is no ideal treatment. FDA-approved drugs include three cholinesterase inhibitors, such as Donepezil, Galantamine, and Rivastigmine, and an excitatory amino acid receptor antagonist, such as memantine hydrochloride (Memantine), which can improve the symptoms of dementia patients in the short term but cannot delay the progression of the disease. At present, scholars at home and abroad have begun to pay attention to the application research of the active ingredients of traditional Chinese medicine, especially the compound prescription of traditional Chines...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/16A61K9/20A61K9/48A61P25/28
Inventor 田金洲王永炎时晶尹军祥盛树力
Owner 田金洲
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