Application of herba epimedii acidic polysaccharose with effect of resisting neurodegenerative disease in preparation of food

A neurodegenerative and acidic polysaccharide technology, which is applied in nervous system diseases, neuromuscular system diseases, polysaccharide/gum-containing food ingredients, etc., to improve survival rate, enhance the ability to scavenge free radicals, and increase the activity of antioxidant enzymes.

Inactive Publication Date: 2015-04-22
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As an important traditional Chinese medicine, modern clinical trials and studies have shown that the active ingredients of Epimedium have a wide range of pharmacological activities and medicinal functions: anti-inflammation, anti-pathogenic microorganisms, anti-oxidation, anti-tumor and anti-aging effects, but currently people The study and application of epimedium polysaccharides, especially epimedium acidic polysaccharides, in neuroprotection have not been reported yet

Method used

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  • Application of herba epimedii acidic polysaccharose with effect of resisting neurodegenerative disease in preparation of food
  • Application of herba epimedii acidic polysaccharose with effect of resisting neurodegenerative disease in preparation of food
  • Application of herba epimedii acidic polysaccharose with effect of resisting neurodegenerative disease in preparation of food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The epimedium acidic polysaccharide provided by this example is prepared by the following method, such as figure 1 As shown in , the raw material Epimedium was taken, and the degreasing treatment was carried out with 95% ethanol aqueous solution, the solid-liquid ratio was 1g:10mL, the extraction temperature was 60°C, the degreasing time was 4h, and the degreasing treatment was performed 3 times. Take the degreased Epimedium, add water to extract, the ratio of solid to liquid is 1g:10mL, the extraction temperature is 80°C, the extraction time is 4h, and a total of 4 extractions are taken, the extracts are combined, and the extracts are concentrated under reduced pressure at 50°C , to obtain the concentrated solution, the concentrated solution is carried out alcohol precipitation treatment with a 95% ethanol aqueous solution by volume percentage, the volume ratio of the 95% ethanol aqueous solution to the concentrated solution is 1:4, and the precipitate, water After dis...

Embodiment 2

[0033] The epimedium acidic polysaccharide provided by this example is prepared by the following method, such as figure 1As shown in , the raw material Epimedium was taken, and the degreasing treatment was carried out with 80% ethanol aqueous solution by volume, the solid-liquid ratio was 1g:20mL, the extraction temperature was 70°C, the degreasing time was 4h, and the degreasing treatment was performed 3 times. Take degreased Epimedium, add water to extract, the ratio of solid to liquid is 1g:20mL, and the extraction temperature is 90°C, extract 3 times in total, combine the extracts, and concentrate the extracts at 50°C under reduced pressure to obtain a concentrated solution , the concentrated solution is subjected to alcohol precipitation treatment with 95% ethanol aqueous solution by volume percentage, the volume ratio of 95% ethanol aqueous solution to the concentrated solution is 1:4, the precipitate is taken, dissolved in water, and The Sevage method removes the protei...

Embodiment 3

[0036] The epimedium polysaccharide provided by this example is prepared by the following method, such as figure 1 As shown in , the raw material Epimedium was taken, and the degreasing treatment was carried out with 70% ethanol aqueous solution, the solid-liquid ratio was 1g:30mL, the extraction temperature was 90°C, the degreasing time was 4h, and the degreasing treatment was performed 3 times. Take the degreased Epimedium, add water to extract, the ratio of solid to liquid is 1g:30mL, and the extraction temperature is 100°C, extract twice in total, combine the extracts, and concentrate the extracts at 50°C under reduced pressure to obtain a concentrated solution , the concentrated solution is subjected to alcohol precipitation treatment with 95% ethanol aqueous solution by volume percentage, the volume ratio of 95% ethanol aqueous solution to the concentrated solution is 1:4, the precipitate is taken, dissolved in water, and The Sevage method removes the protein, wherein th...

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Abstract

The invention discloses an application of herba epimedii acidic polysaccharose with an effect of resisting neurodegenerative disease in preparation of food, particularly relates to application in health food and discloses a preparation method for the herba epimedii acidic polysaccharose. The preparation method comprises the following steps: with herba epimedii as raw material, degreasing, performing water extraction and alcohol precipitation, removing protein, performing ion exchange, dialyzing and drying. The method is simple to operate, high in polysaccharose yield, low in cost, efficient and practical, is prepared from easily available materials and is suitable for industrial production. According to a test on a caenorhabditis elegans disease-associated neurodegenerative disease model, the herba epimedii acidic polysaccharose can be used for remarkably strengthening the capacities of removing free radical in vitro, improving in-vivo antioxidant enzyme activity, inhibiting production of lipid peroxide, increasing the survival rate of caenorhabditis elegans under an oxidative stress condition, relieving nerve injury caused by abnormal aggregation of the polyglutamine toxic proteins under the oxidative stress condition, and has a good nerve protection effect.

Description

technical field [0001] The invention belongs to the technical field of food, and further belongs to the technical field of health food (also called health food or functional food), and specifically relates to the application of epimedium acid polysaccharide with anti-neurodegenerative disease effect in preparing food. technical background [0002] At present, with the acceleration of the global aging process, age-related neurodegenerative diseases (such as: Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease) have become serious threats to human life and health and reduce life. The quality of major diseases, in-depth understanding of the pathogenesis of such diseases, and the development of products that alleviate the symptoms of such diseases will all make important contributions to human health. Modern studies have shown that the body in a stressful environment will aggravate the abnormal aggregation of neurodegenerative disease-related toxic proteins,...

Claims

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Application Information

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IPC IPC(8): A23L1/09A61K31/715A61P25/14A61P25/28A61P21/00A23L33/125
CPCA23V2002/00A61K36/00A23V2250/51A23V2300/14
Inventor 马忠华胡明华陈伟鸿马方励
Owner INFINITUS (CHINA) CO LTD
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