4 results about "Dimethyl Sulphone" patented technology

The object of this invention is a lipophilic activity modifier in the form of dimethyl sulfone (MSM) for use as a transdermal penetration enhancer for high molecular weight active substances with a molecular weight (Mw) > 500 Da. Another object of this invention is a cosmetic composition for transdermal application comprising an active substance and a transdermal penetration enhancer, characterized in that the active substance is encapsulated by the transdermal penetration enhancer, which is the lipophilic activity modifier according to claim 1, and the active substance is a high molecular weight active substance with a molecular weight (Mw) > 500 Da. Another object of the present invention is a method for preparing a composition according to the invention, characterized in that the method is carried out by thermal emulsification or cold emulsification, wherein thermal emulsification comprises the following steps: a) mixing dimethyl sulfone and a diluent in a reaction vessel; b) bringing the mixture to 70-85°C; c) stirring the mixture at 70-85°C; the start of homogenization depends on the stage of phase combination; d) cooling the mixture to 20-40°C, preferably 30°C; e) adding a high molecular weight active substance with Mw>500 Da and homogenizing the mixture, preferably for 1-3 min; while cold emulsification comprises the following steps: a) mixing dimethyl sulfone and a diluent in a reaction vessel and dissolving at a temperature maintained at 20-25°C; b) bringing the mixture to a temperature of 15-35°C, preferably ambient temperature or 25°C; c) stirring the mixture at a temperature of 15-80°C, preferably 25°C; the start of homogenization depends on the stage of phase combination; d) adding a high molecular weight active substance with Mw>500 Da and homogenizing the mixture, preferably for 1-3 min.

The present invention discloses a multi-component synovitis therapeutic composition based on cartilage tissue repair and a use thereof, relating to the technical field of biomedicine. The composition comprises glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone, and graded molecular weight sodium hyaluronate. By compounding these components in precise parts by weight, the present invention constructs a gradient sustained-release and targeted delivery system for synovitis lesions. Dimethyl sulfone specifically inhibits hyaluronidase activity in the inflamed joint cavity, significantly reducing sodium hyaluronate degradation and prolonging the retention time of each active ingredient at the lesion site. High molecular weight sodium hyaluronate rapidly forms a lubricating protective film to achieve immediate analgesia and relieve ankylosis, while medium- and low-molecular-weight sodium hyaluronate penetrates the synovial barrier and carries cartilage repair components to the cartilage defect area, thereby achieving synergistic enhancement and comprehensively improving synovitis treatment efficacy.

The application discloses a method for preparing polyether sulfone by a nucleophilic substitution reaction, and discloses the following steps: taking dimethyl sulfone as a solvent, canceling a double-phenol S / potassium carbonate salification mode, and replacing the double-phenol S / potassium carbonate salification mode with cheap sodium hydroxide / potassium hydroxide, so that the cost is reduced; the whole polymerization process does not emit carbon dioxide; the reaction temperature is increased, the molecular activity is strong, the reaction time is shortened, and the polymerization efficiency is improved; the product is porous after ethanol washing, water can enter the inside of the particles during water washing, salt is washed out, and the salt content in the finished product resin is reduced; no solvent hydrolysis phenomenon occurs in the polymerization process, no N-methyl-4-hydroxyaminobutyric acid is generated, and the product has high purity; the polymerization is a full solid-state feeding process, and no solvent needs to be supplemented, so that the method is a simple and efficient polymerization method and can be applied to industrial production.

The invention relates to a method and an apparatus for enlarging particles of an aerosol and to the use of an operating agent for producing a supersaturated vapor. In a method for enlarging particles (1) of an aerosol (2), the particles (1) come into contact with a supersaturated vapor (3). A sulfoxide or a sulfone such as dimethyl sulfoxide or dimethyl sulfone is used to produce the supersaturated vapor (3). These substances are non-flammable, non-hazardous to health, non-hazardous to the environment and therefore easy to handle. There is no odor nuisance or climatic damage. The same particle counting efficiencies are achieved as with the commonly used butanol as an operating agent.