64 results about "Dimethyl Sulphone" patented technology

The invention relates to a preparation method for synthesizing an apremilast intermediate. The preparation method comprises the following steps of: carrying out condensation reaction on 3-ethoxyl-4-methoxyl-benzoate and dimethyl sulfone under an alkaline condition to generate 2-(3-ethoxy-4-methoxyphenyl)-1-methylsulfonyl acetone; reacting the compound II and chiral amine in the presence of an acidic catalyst to obtain 1-N-substituted amino-1-(3-ethoxyl-4-methoxyl) phenyl-2-methylsulfonyl ethylene (III), and directly hydrogenating the obtained compound III in the presence of a hydrogenation catalyst without separating the compound III to obtain a product (S)-1-(3-ethoxyl-4-methoxyl) phenyl-2-methanesulfonyl ethylamine (I), namely the apremilast intermediate, wherein the apremilast intermediate can be further prepared into N-acetyl L-leucinate. The invention also provides a preparation method of apremilast. The preparation method disclosed by the invention has the advantages of simple process flow, safety, environmental friendliness and low cost and is favorable to clean industrialized production.

The invention relates to a method for recovering dimethyl sulfone and sodium nitrate from dimethyl sulfoxide waste slag, which comprises arranging waste slag waste slag in a decompression autoclave at 120-160DEG C to decompress and distill, distilling out the dimethyl sulfoxide and dimethyl sulfone from dimethyl sulfoxide waste slag to be arranged into an another autoclave to be cooled to obtain crystallized solid, arranging the distilled dimethyl sulfoxide and dimethyl sulfone into enough hydrogen dioxide solution to be oxidized and dried in vacuum to obtain dimethyl sulfone product, dissolving leavings in water to be discharged, adding concentrated nitric acid into the filtered mother liquid to adjust pH till 2-3 and convert sodium nitrite to sodium nitrate, neutralizing over nitric acid via soda, to neutralize the mother liquid, heating the solution to 120-125DEG C, evaporating at normal pressure, cooling to 50-70DEG C, crystallizing, separating and drying to obtain sodium nitrate product. The invention can reduce discharge of industrial waste slag and reduce environment pollution, with simple process and low energy consumption.

The present invention discloses glucosamine composite tablets and a preparation method thereof, and belongs to the field of purposes of health food. On the basis of combination of glucosamine and calcium supplements, the glucosamine complex tablets further comprise active ingredients comprising the following materials: 100 to 400 parts of chondroitin sulfate, 100 to 400 parts of dimethyl sulfone, 100 to 400 parts of collagen, 1 to 40 parts of olive oil, 1 to 5 parts of sodium hyaluronate, and other auxiliary materials which comprise the following materials: 1 to 5 parts of a glidant, 1 to 5 parts of a lubricant and 1 to 10 parts of a coating premix agent. A mineral premix agent includes 1 to 5 parts of a boron agent, 1 to 5 parts of a manganese agent and 1 to 5 parts of a copper agent. The glucosamine complex tablets are further added with active ingredients with effects of enhancing cartilage, joint synovial fluid and bone density. The preparation method of the glucosamine complex tablets adopts a wet granulation process, and adequately overcomes problems of single product efficacy, low absorption and utilization rate in conventional glucosamine type health food.

The invention discloses a compound preparation of glucosamine chondroitin. The compound preparation comprises the following main components of: glucosamine salts and chondroitin sulfate as main active components, one or several of dimethyl sulfone and collagen as auxiliary components and an accessory. Mixed granules produced by the compound preparation disclosed by the invention have better compressibility and stability; the consumption of the accessory is reduced, so that the production cost is reduced; the quality of products is reduced; and the compound preparation is especially suitable for middle-aged groups suffering from rheumatic arthritis and groups whose moving joints are injured.

The invention provides a preparation method for dimethyl sulfone. The method comprises the step of subjecting a liquid mixture to passing through a catalyst bed filled with at least one titanium-silicon molecular sieve in a fixed bed reactor under the condition of oxidation reaction so as to obtain a mixture containing dimethyl sulfone, wherein the liquid mixture comprises dimethyl sulfide and at least one peroxide; and the mol ratio of the peroxide to the dimethyl sulfide is more than 2: 1. According to the invention, with peroxide as an oxidant, the method has low corrosiveness to equipment, releases few environmental pollutants, can obtain high conversion rate of dimethyl sulfide and selectivity of dimethyl sulfone, and has high effective utilization rate of the oxidant at the same time.

The invention provides a composition for animals. The composition contains CBD or a hemp extract. The hemp extract contains CBD. The composition contains (by mass): 0.5-5% of CBD, 2-15% of dimethyl sulfone, 2-15% of glucosamine or salt thereof, 0.1-5% of chondroitin sulfate, 0.0001-0.005% of colloidal silver and 60-95% of water. The composition can be applied to preparation of animal medicines ordaily chemical products for animals.

The invention relates to a method for separating phenol, arene and alkane in direct coal liquefaction effluent through a one-step method. The method comprises the steps that dimethyl sulfoxide or mixed solvent of dimethyl sulfone and sulfolane is selected as extracting solvent (solvent A for short), and the direct coal liquefaction effluent is directly divided into phenol, arene and alkane through an extraction and rectification means. Obtained cycloparaffin can be directly taken as fuel, the obtained arene can be taken as a chemical material, and a mixture of a phenolic compound and the solvent A which are retained at the kettle bottom can be subjected to water-organic solvent (solvent B for short) extraction to obtain the phenol. According to the method, the liquefaction effluent can be directly divided into the three compounds, and the advantages that the product purity is high, the operating technology is simple, the system energy consumption is low, and equipment is not corroded due to the fact that acid and base are not used are achieved; in addition, the solvent A, the solvent B and water which are used in the method can be recycled, therefore, waste liquid discharge is reduced, and environmental protection is facilitated.

The invention belongs to the field of organic synthetic chemistry, and in particular relates to a preparation method of dimethyl sulfone as well as used catalyst and catalyst composition thereof. The general formula of the catalyst is aFe2O3.bMnO2.cTiO2.dRh203.eRuO2, wherein a, b and c are selected from 0 to 15 independently, and d and e are selected from 0.01 to 10 independently. The catalyst composition comprises the catalyst and photosensitizer with the mass ratio of 1:0.01 to 10. The catalyst/catalyst composition has efficient catalytic activity, oxygen is taken as single oxidant during a process of catalyzing dimethylsulfide or dimethyl sulfoxide to prepare dimethyl sulfone, and compared with a conventional nitric acid technique and a potassium permanganate method, the preparation method has the advantages that during preparation, any hazardous substances can not be caused, and pollution is not caused to the environment.

The invention discloses a making method of 3, 4-difluo-trifluoro toluene, which comprises the following steps: adding 3-nitro-4-chloride trifluoro toluene and anhydrous potassium fluoride with molar rate at 11. 5-4 in the N, N-dimethyl formamide, dimethyl sulfoxide, N-methyl pyrrolidone, dimethyl sulphone or N, N-dimethyl acetyl solvent; stirring under 120-180 deg. c; filtering to remove inorganics; decompressing; rectifying; obtaining 3-nitro-4-chloride trifluoro toluene; adding 3-nitro-4-chloride trifluoro toluene and ammonium fluoride tetramethyl, ammonium fluoride tetraethyl, ammonium fluoride tetrapropyl or ammonium fluoride tetrabutyl with molar rate at 12-6 in the tetrahydrofuran, dioxi-hexacyclic ring or N, N-dimethyl formamide solvent; stirring under 25-110 deg. c; rectifying to obtain the product.

The invention provides an aquogel scalding surgical dressing and a preparation method thereof. The method comprises the following steps of: adding dimethyl sulphone into polyvinyl alcohol solution to obtain mixed solution, wherein a weight ratio of the dimethyl sulphone to the polyvinyl alcohol solution in the mixed solution is (0.01-10):100; performing film casting on the mixed solution; and freezing and crosslinking the solution subjected to film casting repeatedly to obtain the aquogel scalding surgical dressing. The aquogel scalding surgical dressing prepared according to the method has high biocompatibility and wettability, and can promote cell neogenesis, accelerate the healing of wounds, stop bleeding, relieve pain and reduce the pain of patients.

The invention discloses a method for simultaneously producing dimethyl sulfone and dimethyl sulfoxide. The method comprises the steps that firstly, methyl sulfide reacts under the condition that dimethyl sulfone can be formed, a mixture containing dimethyl sulfone is obtained, and after dimethyl sulfone is freely separated out of the mixture and is further in contact and reacts with the other part of methyl sulfide, an unreacted oxidizing agent is utilized for oxidizing methyl sulfide to form dimethyl sulfoxide. The conversion rate of the oxidizing agent is effectively improved, running cost is reduced, and the requirement for subsequent residual oxidizing agent treatment and other steps is lowered. According to the method, high target oxidation product selectivity can be achieved during the two-step oxidizing reaction.

The invention discloses a dimethyl sulfone preparation method. The dimethyl sulfone preparation method comprises causing dimethyl sulfoxide and at least one oxidizing agent to be in contact with at least one titanium silicate molecular sieve under the conditions of oxidation reaction, wherein the at least part of the titanium silicate molecular sieve is a non-fresh titanium silicate molecular sieve. Compared with a method of causing dimethyl sulfoxide to undergo contact reaction with the oxidizing agent in the absence of catalysts, the dimethyl sulfone preparation method can achieve the obviously improved dimethyl sulfoxide conversion rate, the effective utilization rate of the oxidizing agent and dimethyl sulfone selectivity. Compared with a method of causing dimethyl sulfoxide and the oxidizing agent to undergo contact reaction with a fresh titanium silicate molecular sieve, the dimethyl sulfone preparation method can achieve a higher effective utilization rate of the oxidizing agent, and in the long-cycle continuous reaction process, the conversion rate of dimethyl sulfoxide and the selectivity of dimethyl sulfone are more stable. In addition, the method is moderate in reaction conditions, easy to control and suitable for devices of various production scales.

The present invention discloses a method for synthesizing 2-acetyl phenothiazine using phenothiazine as a raw material. The method comprises: by using silicon dioxide as a catalyst, heating phenothiazine with formic acid by microwave radiation for a nucleophilic substitution reaction; conducting an electrophilic substitution reaction on the product obtained in the first step and acetyl chloride under catalysis of aluminium trichloride in a dimethyl sulphone solvent; and conducting a hydrolysis reaction on the product obtained in the second step under catalysis of a strong base. According to the method provided by the invention, phenothiazine is used as the raw material, and through N-formylated nucleophilic substitution, electrophilic substitution on benzene rings and hydrolysis of N-acylamino, 2-acetyl phenothiazine is obtained. According to the method disclosed by the invention, secondary amine is formylated in the method to weaken the positioning effect of N atoms on phenyl rings in ortho-position and para-position of the N atoms, so that the leading role of S atoms on the positioning effect in the ortho-position and the para-position of the S atoms s ensured, and the yield of a target product 2-position acetyl substituted product is significantly improved, thereby ensuring the total yield and purity of 2-acetyl phenothiazine.

The invention discloses an aqueous lithium ion electrolyte, which is characterized in that the electrolyte is formed by compounding dimethyl sulfone, lithium perchlorate, urea and water according to amolar ratio of (0.5-2): (0.5-1.6): (0.5-2): (0.3-2), and is a transparent homogeneous solution obtained by mixing and grinding four raw materials and then placing the mixture in a water bath for ultrasonic treatment. According to the invention, cheap non-flammable organic small molecules, lithium salt and water are creatively adopted to act together to broaden an electrochemical stability window,the prepared electrolyte has high ionic conductivity, low viscosity and good high and low temperature phase stability retentivity, the whole preparation process is simple and easy to implement, the preparation cost is reduced, and the electrolyte is very beneficial to realize industrial production.

The invention relates to a composition for pets and an application thereof. The composition for the pets comprises a cannabidiol-containing raw material, dimethyl sulfone, glucosamine sulfate, menthol, thymol, vitamin B2 and active silver ions. The components in the composition for the pets cooperate with one another to achieve a synergistic effect, so that the composition can prevent and treat oral diseases of the pets, protect oral health of the pets and effectively improve various symptoms caused by pet arthritis, and also has the effects of relieving pet dysphoria and anxiety and calming and relieving pet mood. When being used for preparing a pet spray, the composition can be administrated through oral mucosa, and has the advantages of quick effect taking and high bioavailability.

The embodiments of the present invention disclose a composition, a preparation method thereof and an application of the composition in preparing joint maintenance medicines, health-care products and food. The composition comprises the following materials in parts by mass: 71-169 parts of glucosamine, 60.8-144.8 parts of dimethyl sulfone, 101.4-241.4 parts of perna canaliculus, 2.5-6.0 parts of collagen, 5.1-12.1 parts of bone glue, 71-169 parts of enzymatic bone meal and 71-169 parts of a cartilage extract. The composition starts from three aspects of slowing pains, controlling inflammation and promoting cartilage healing, works together to fundamentally maintain joints, and prevent and repair joint diseases, is free of toxic and side effects, and can be consumed for a long time.

The invention discloses a dimethyl sulfone preparation method. The method comprises causing a liquid mixture to be in contact with a catalyst in a reaction area in a catalytic distillation reactor provided with at least one reaction zone, so as to obtain material flow containing dimethyl sulfone, wherein the liquid mixture contains dimethyl sulfide and at least one oxidizing agent. The method can achieve high dimethyl sulfoxide conversion rate, dimethyl sulfone selectivity and effective utilization rate of the oxidizing agent. Besides, the method can make full use of reaction latent heat and even enables an oxidation product to be separated while the oxidation product reacts with raw material dimethyl sulfoxide, so that the follow-up separation cost is reduced, and energy saving and emission reduction are achieved.

The invention discloses a dimethyl sulfone preparation method. The dimethyl sulfone preparation method comprises causing a liquid mixture to be in contact with at least one titanium silicalite molecular sieve in a reaction zone in a catalytic distillation reactor with at least one reaction zone, so as to obtain material flow containing dimethyl sulfone, wherein the liquid mixture contains dimethyl sulfoxide and at least one oxidizing agent. The method can achieve high dimethyl sulfoxide conversion rate, dimethyl sulfone selectivity and effective utilization rate of the oxidizing agent. Besides, the method can make full use of reaction latent heat and even enables an oxidation product to be separated while the oxidation product reacts with raw material dimethyl sulfoxide, so that the follow-up separation cost is reduced, and energy saving and emission reduction are achieved.

The invention relates to a long-acting antibacterial agent, which comprises the following components: dimethyl sulfone, waterborne polyester polyol, an initiator and a chain extender. The effective component dimethyl sulfone in the non-toxic long-acting antibacterial agent can destroy the living environment of bacteria, effectively reduce the reproduction speed of various bacteria and cannot causethe variation of the bacteria, so that the long-term effective antibacterial effect is achieved; after dimethyl sulfone with a small molecular structure is grafted to a structural unit of water-basedpolyester polyol, the long-acting antibacterial agent can be effectively attached to the surface of an object for a long time to form a layer of tightly cross-linked film, and the attachment durationof effective components is prolonged, so that the actual use effect of the long-acting antibacterial agent is prolonged, the antibacterial frequency is reduced, and a long-term antibacterial effect is achieved.

The invention provides a preparation method of a polyethylene microporous membrane. The method comprises the following steps: mixing 20-60wt% of polyethylene and 40-80wt% of a composite diluent to obtain a premix; carrying out melt extrusion and cooling molding on the premix to obtain a primary membrane; and removing the composite diluent in the primary membrane by adopting an extracting agent, and then carrying out heat treatment to obtain a polyethylene microporous membrane. The composite diluent comprises a high-temperature solvent and a non-solvent, the high-temperature solvent is selectedfrom one or more of tetradecanoic acid, hexadecanoic acid, octadecanoic acid, eicosanoic acid, docosanoic acid, tetradecanol, hexadecanol, octadecanol and eicosanol, the non-solvent is selected fromone or more of benzophenone, diphenyl carbonate and dimethyl sulfone, and the high-temperature solvent accounts for no less than 60 wt%. By adopting the specific composite diluent, liquid-liquid phaseseparation can still occur when the polymer concentration is high in the phase separation process, and the obtained polyethylene microporous membrane has excellent air permeability and mechanical strength and is suitable for being used as a lithium battery diaphragm material.

The invention provides a traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following components in parts by weight of 5-15 parts of ligusticum wallichii, 5-15 parts of rhizoma gastrodiae, 10-30 parts of kadsura pepper stems, 5-15 parts of radix angelicae pubescentis, 5-15 parts of fresh ginger sheets,5-15 parts of safflowers, 5-15 parts of Pseudo-ginseng, 5-15 parts of radix clematidis, 5-15 parts of erodium stephanianum willd, 5-15 parts of turmeric, 5-15 parts of borneol, 5-15 parts of Tibet snow lotus flowers, 5-15 parts of prepared rehmannia roots, 5-15 parts of radix astragali, 1-3 parts of capsaicine, 5-15 parts of radix angelica sinensis, 0.5-1.5 parts of ginseng, 0.5-1.5 parts of dimethyl sulfone, 2.5-7.5 parts of peppermint essence oil, 1-3 parts of fresh ginger essential oil, 1-3 parts of argy wormwood leaf essential oil and 90-240 parts of Baijiu. The traditional Chinese medicine composition has notable treatment effects of treating and preventing arthritis (particularly rheumatoid arthritis ), psoatic strain and sciatica, can eliminate pain caused by lumbar disc herniation, and can completely heal tendon and bone pain caused by attack by wind. The problems that at current, in the markets, medicines are difficult for effective treatment of symptoms, and are high in toxic and side effects are solved.

The invention discloses a preparation method of dimethyl sulfone. The method includes the step of making dimethyl sulfoxide make contact with at least one oxidant and at least one titanium silicalite molecular sieve serving as the catalyst in a reaction area of a reactor under the oxidation reaction conditions, wherein in the contact process, the titanium silicalite molecular sieves move in the reaction area in the axial direction of the reactor. According to the method, the problem that temperature runaway of a catalytic bed probably happens to a fixed bed reactor can be effectively solved, the high dimethyl sulfoxide conversion rate, oxidant effective utilization rate and dimethyl sulfone selectivity can be achieved, and the service life of the catalyst can be prolonged; meanwhile, without shutting down equipment, the titanium silicalite molecular sieves of which the activity does not meet the requirement can be removed out of a reactor system for regeneration.

A non-aqueous electrolyte secondary battery having a positive electrode, a separator, a negative electrode opposed to the positive electrode via the separator, and a liquid electrolyte wherein the liquid electrolyte includes a lithium salt, methyl acetate, and dimethyl sulfone. The content ratio of methyl acetate in the liquid electrolyte is 10% by mass to 40% by mass, and the content ratio of dimethyl sulfone in the liquid electrolyte is 0.1% by mass to 5% by mass.

The invention provides a novel method for synthesizing an isotopic hydroxyl and methylsulfonyl methyl compound. The method comprises the following steps: carrying out low-temperature lithiation reaction on a keto-carbonyl raw material compound and dimethyl sulfone, and carrying out one-step synthesis to obtain an isotopic hydroxyl and methylsulfonyl methyl series compound in situ on keto-carbonyl.According to the novel preparation method of the isotopic hydroxyl and methylsulfonyl methyl compound, the whole synthesis route is short in step, good in repeatability, wide in application substrate, high in yield, mild in operation condition and high in safety, and large-scale production and industrial popularization and application are facilitated.