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Enhancer of the effect of adrenocorticoid, comprising gum arabic

A technology of corticosteroids and adrenal glands, applied to medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, plant raw materials, etc., to achieve the effect of effective treatment methods

Inactive Publication Date: 2008-07-30
弗里特隆有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several corticosteroids are used to treat nephritis, but these hormones are associated with many side effects

Method used

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  • Enhancer of the effect of adrenocorticoid, comprising gum arabic
  • Enhancer of the effect of adrenocorticoid, comprising gum arabic
  • Enhancer of the effect of adrenocorticoid, comprising gum arabic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0094] Preparation of drinking reagents

[0095] The water-soluble gum (10 g) was dissolved in hot water (40°C, 30 mL) while stirring. After cooling the solution to 25°C, vitamin B1 (10 mg), vitamin B6 (10 mg), caffeine (50 mg), sugar (5 g), honey (5 g), citric acid (400 mg), sodium citrate were added under stirring (50mg) and sodium benzoate (35mg). The pH of the resulting solution was adjusted to 6.0 by adding lactic acid and 0.1 N sodium hydroxide. Then, the total volume of the resulting solution was adjusted to 50 mL by adding water.

[0096] The water-soluble gum used in this example was prepared by pulverizing and dissolving gum arabic from the Senegalese acacia tree in Sudan. Then, the resulting solution was filtered and the filtrate was spray dried to provide the water soluble gum.

[0097] industrial application

[0098] The present invention provides an effective therapeutic method for nephritis treatment by increasing the efficacy of corticoid therapy because...

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Abstract

This invention provides an enhancer of the effect of adrenocorticoid on nephritis without enhancement of the undesirable side-effects of the adrenocorticoid, comprising the water-soluble gum obtained from the stem and / or branch of Acacia species, e.g., Gum Arabic. The combination of the adrenocorticoid and the water-soluble gum enhances the effect of the adrenocorticoid on nephritis without enhancement of the undesirable side-effects of the hormone agent.

Description

technical field [0001] The present invention relates to a potentiator of the effect of adrenal corticoids, in particular a water-soluble gum comprising stems and / or branches from the species of acacia species, which enhances the protective effect of said adrenal corticoids against nephritis without Undesirable side effects of corticosteroids may be increased. Background technique [0002] Adrenocorticoids are biosynthesized in and secreted from the adrenal gland. The hormones are divided into two classes, mineralocorticoids such as aldosterone and deoxycorticosterone with electrolyte metabolic activity and glucocorticoids such as cortisone and hydrocortisone with hepatic glycogen activity or glucocorticoid activity. Since the latter class has various pharmacological activities, such as antiallergic, anti-inflammatory and immunosuppressive activities, various glucocorticoids have been synthesized. [0003] As a result of in-depth chemical investigations, several potent anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61K31/58A61K31/573A61P13/12
CPCA61K36/48A61K31/573A61K31/57A61K31/58A61P13/12A61P43/00A61P5/06A61K2300/00
Inventor 久保道德松田秀秋
Owner 弗里特隆有限公司