Externally-applied drug delivery preparations containing bullatacin part medicine exquisite articles
A part and high-quality technology, which is applied in the field of topical drug preparations containing bratasine part medicine, can solve problems such as toxic and side effects, achieve the effect of less damage to normal cells, reduce viral load, and improve immune function
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Embodiment 1
[0019] Example 1: Get 6 kg of washed and dried custard apple seeds and pulverize them to 40-50 meshes, add 95% alcohol to soak and extract for 18-20 hours (repeated 4 times), concentrate under reduced pressure to recover the alcohol, add 800 ml each of water and petroleum ether Fully shake, after standing for stratification, back extraction with 78% alcohol (800ml each time, repeated 6 times), after standing for stratification, release the lower layer stripping solution (5600ml), after decompression and recovery of alcohol, to obtain 180g of total lactones in custard apple. Mix well with 270g of silica gel (100-200 mesh) and total annona lactones, then dry it and set aside. Use 450g of silica gel (100-200 mesh) to dry-pack the column, then add the prepared mixed sample silica gel for column chromatography, and use petroleum ether-acetone mixture (95:5, 92:8, 90:10, 88: 12) Elution with the eluent, collect and recover acetone and petroleum ether, and combine the required activ...
Embodiment 2
[0021] Dissolve 198g of local medicinal products containing bullatacin in 1100ml of a mixture of absolute ethanol and propylene glycol (volume ratio 1:1), stir thoroughly to mix the medicine and the mixture evenly, and follow the paste 20400 patches (size: 7×10cm) were made by using the production method of the patch.
Embodiment 3
[0023] Dissolve 168g of the local drug essence containing bullatacin in 1200ml of a mixed solution of absolute ethanol and propylene glycol (volume ratio is 1:1), stir well, and after the medicine and the mixed solution are completely mixed, follow the gas The production method of spray and film is made into aerosol and film.
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