Preparation technique of sodium hyaluronate gel granule

A technology of sodium hyaluronate and gel particles, which is applied in the fields of medical science, prostheses, coatings, etc., can solve the problems of complicated preparation methods, and achieve the effects of simple process, increased safety, and good cross-linking effect.

Inactive Publication Date: 2008-09-17
SHANDONG KAILEPU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the Chinese patent application whose publication number is CN 1590444A discloses a method for preparing sodium hyaluronate gel by using 1,4-butanediol diglycidyl ether as a cross-linking agent, there was no high-purity hyaluronic acid raw material at that time. , which requires deproteinization pretreatment, which makes the preparation method more complicated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1. Preparation of cross-linked sodium hyaluronate gel one

[0032] Dissolve 20 grams of hyaluronic acid in 200 ml of 1% sodium hyaluronate solution, keep the temperature of the reaction system at 35°C, stir to make it even, add the crosslinking agent 1,4-butanediol diglycidyl ether, the dosage is transparent 5% by weight of sodium hyphenate, and continued to stir for 2 hours to obtain a colorless transparent gel.

Embodiment 2

[0033] Embodiment 2. Preparation two of cross-linked sodium hyaluronate gel

[0034] Dissolve 20 grams of hyaluronic acid in 160 milliliters of 2% sodium hyaluronate solution, keep the temperature of the reaction system at 30°C, stir to make it even, add the crosslinking agent diglycidyl ether, the dosage is 8% of the weight of sodium hyaluronate , and continued to stir for 2 hours to obtain a colorless transparent hydrogel.

Embodiment 3

[0035] Example 3. Preparation of dialysate

[0036] Dialysate formula 1: Add Na to every 10L of normal saline 2 HPO 4 8.55g, NaH 2 PO 4 1.20g, after 0.45μm precision filtration, use 0.1mol / L hydrochloric acid to adjust the pH value to 7.0.

[0037] Dialysate formula 2: add NaOH 2.1g, NaH 2 PO 4 3.3g, to make the pH of the solution reach 7.2, and filter through 0.45μm for later use.

[0038] Dialysate formula three: Add Na to every 10L of normal saline 2 HPO 4 8.3g, NaH 2 PO 4 22.5g, to make the pH of the solution reach 6.8, and filter through 0.45μm for later use.

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PUM

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Abstract

The invention provides a preparation method of sodium hyaluronate gel particle, which comprises (1) crosslinking reaction for preparation of crosslinking sodium hyaluronate gel, (2) dialysis for the process of hyaluronic acid gel, and (3) grading of gel particle. The preparation method of sodium hyaluronate gel particle has the advantages of excellent crosslinking performance and being suitable for medical cosmetology field, compared with the prior similar gel particle.

Description

technical field [0001] The invention relates to a preparation method of medical gel particles, in particular to a preparation method of sodium hyaluronate particles used for medical cosmetology. Background technique [0002] Sodium hyaluronate is a natural linear polysaccharide, a disaccharide structural unit composed of (1-4)-β-D glucuronic acid and (1-3)-2-acetylamino-β-D glucose composed of. Widely distributed in the connective tissue of mammals, cockscombs, and the capsule of streptococci. Since it does not have species and organ specificity, hyaluronic acid gel particles prepared by cross-linking sodium hyaluronate are used as fillers. Transplantation or injection into the body shows good biocompatibility of the body, plays the role of anti-wrinkle, breast augmentation and cushioning, and has no side effects on the human body. It is widely used in the medical cosmetology industry. [0003] Among them, in the process of preparing hyaluronic acid gel particles, under th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L27/20
Inventor 丁书美梁世平李开明
Owner SHANDONG KAILEPU PHARMA
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