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Applications of Murraya jasminorage leaf total flavones in preparation of medicament for curing diabetes

A diabetes drug, the technology of Jiulixiangye, which is applied in the field of effective parts of traditional Chinese medicine, can solve the problem of lowering the hypoglycemic effect

Inactive Publication Date: 2008-10-08
长春瑞德医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these oral hypoglycemic drugs have side effects such as hypoglycemia and gastrointestinal reactions. At the same time, with the prolongation of treatment time, the hypoglycemic effect tends to decrease.

Method used

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  • Applications of Murraya jasminorage leaf total flavones in preparation of medicament for curing diabetes
  • Applications of Murraya jasminorage leaf total flavones in preparation of medicament for curing diabetes
  • Applications of Murraya jasminorage leaf total flavones in preparation of medicament for curing diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 2 kg of Jiulixiang leaves, reflux and extract 3 times with 85% ethanol, the amount of ethanol is 10, 8, and 6 times respectively, and the reflux time is 60, 45, and 30 minutes respectively, filter, combine the extracts, and concentrate under reduced pressure until there is no ethanol flavor, diluted with water, absorbed by AB-8 macroporous resin, rinsed with 50 liters of sodium hydroxide aqueous solution, washed with water until neutral, eluted with 85% ethanol until JA could not be detected by thin-layer chromatography, and eluted The ethanol is recovered under reduced pressure to obtain the extract of jiulixiang leaves. The extract of the leaves of Jiulixiang was subjected to silica gel column chromatography, and the mixed solution of ethyl acetate and ethanol was used as the mobile phase for gradient elution, the flavonoids were collected, and the solvent was recovered to obtain 38 grams of total flavonoids of the leaves of Jiulixiang. Detected by HPLC, the cont...

Embodiment 2

[0025] Take 10 grams of total flavonoids from leaves of Jiulixiang, add appropriate amount of starch, granulate, pack into capsules, and make 1000 capsules to obtain total flavonoids from leaves of Jiulixiang capsules.

Embodiment 3

[0027] Take 10 grams of total flavonoids from leaves of Jiulixiang, add an appropriate amount of pregelatinized starch and sodium carboxymethyl starch, granulate, and compress into tablets to make 1000 tablets to obtain total flavonoids from leaves of Jiulixiang.

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Abstract

The invention discloses an application of flavonoids of murraya paniculata in the preparation of medicine for treating diabetes mellitus. The flavonoids are extracted from the murraya paniculata leaf and essentially comprise 5, 7, 3', 4'-tetramethoxy flavonoid, 5, 7, 3', 4', 5'-pentamethoxyl flavonoid, 5, 6, 7, 3', 4'- pentamethoxyl flavonoid, 5, 6, 7, 3', 4', 5'-hexamethyl flavonoid, and 7-hydroxyl-5, 3', 4'-trimethyl flavonoid. The results of the animal experiments show that the flavonoids of murraya paniculata can remarkably reduce the blood glucose in T2DM rats, improve the disturbance of lipid metabolism of the T2DM rats, increase the C-peptide level and the content of insulin in the serum of the T2DM rats, improve the excretion index of Beta cells of the insulin and IR, reduce the insulin resistance index, the MDA content in the blood serum of the T2DM rats and the contents of IL-1Beta, IL-6 and TNF-Alpha in the serum of the T2DM rats, and improve SOD activity. The test proves that the flavonoids of murraya paniculata have remarkable efficacy on the diabetes mellitus.

Description

[0001] The invention relates to an effective part of a traditional Chinese medicine that has a therapeutic effect on diabetes, and belongs to the field of traditional Chinese medicine. Background technique [0002] At present, the morbidity and mortality of diabetes are gradually increasing, and it has become the third largest disease that endangers human health after tumors and cardiovascular and cerebrovascular diseases. Although the incidence of diabetes in my country is not high compared with foreign developed countries, my country With a large population, the absolute number of patients ranks first in the world. Therefore, finding safe and effective drugs for the prevention and treatment of diabetes has become one of the important topics of medical research. Oral hypoglycemic agents currently used in the treatment of type 2 diabetes include: sulfonylureas, biguanides, insulin sensitizers, insulin secretagogues, and aldose reductase inhibitors. However, these oral hypoglyc...

Claims

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Application Information

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IPC IPC(8): A61K36/75A61P3/10A61K127/00
Inventor 金永日睢大员李绪文于晓风桂明玉曲绍春
Owner 长春瑞德医药科技有限公司
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