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Liquid oral vaccine for curing blue-ear pig disease and method of preparing the same

A technology for porcine PRRS and oral liquid, which can be applied to diseases, antiviral agents, liquid delivery, etc., and can solve the problem of enhanced safety of ancestral virulence, limited immunity of inactivated vaccines, and uncertainties in the prevention and treatment of PRRS and other issues to achieve the effect of improving the body's immunity

Inactive Publication Date: 2008-10-08
湛江市海科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the phenomenon of increased atavistic virulence and safety issues of attenuated PRRS vaccines have increasingly aroused people's concerns
At home and abroad, the use of attenuated vaccines has caused many PRRS outbreaks in pig herds. Therefore, live vaccines should be used with caution; while the immune efficacy of inactivated vaccines is very limited or uncertain, which has brought great challenges to the prevention and treatment of pig PRRS. uncertainty

Method used

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  • Liquid oral vaccine for curing blue-ear pig disease and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment one: preparation of oral liquid 1 of the present invention

[0019] (1) Weigh 5 grams of knotweed, 10 grams of bean root, 12 grams of breviscapine, 15 grams of windproof, 20 grams of golden buckwheat, 15 grams of eucalyptus, 10 grams of safflower, 2 grams of snake gall, 10 grams of ox gall, and aloe 40 grams, rock sugar 25 grams, ceftiofur sodium 5 grams, levofloxacin 5 grams.

[0020] (2) Add water to decoct the raw materials except ceftiofur sodium and levofloxacin twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1 hour, Combine the two decoctions, filter to obtain the filtrate, concentrate it into an extract with a specific gravity of 1.35, add 85-95% edible glacial acetic acid for extraction, recover the glacial acetic acid and concentrate, dry at 45-50°C to obtain a dry extract 13.76 grams;

[0021] (3) the dry extract is pulverized into powder, add 5 grams of...

Embodiment 2

[0023] Embodiment two: preparation of oral liquid 2 of the present invention

[0024] (1) Weigh 10 grams of knotweed, 15 grams of bean root, 18 grams of escutellaria, 20 grams of windproof, 25 grams of golden buckwheat, 20 grams of eucalyptus, 20 grams of safflower, 5 grams of snake gall, 20 grams of ox gall, and aloe 60 grams, rock sugar 40 grams, ceftiofur sodium 10 grams, levofloxacin 10 grams.

[0025] (2) Add water to decoct the raw materials except ceftiofur sodium and levofloxacin twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1 hour, Combine the two decoctions, filter to obtain the filtrate, concentrate it into an extract with a specific gravity of 1.35, add 85-95% edible glacial acetic acid for extraction, recover the glacial acetic acid and concentrate, dry at 45-50°C to obtain a dry extract 22.77 grams;

[0026] (3) The dry extract is pulverized into powder, add 8 grams...

Embodiment 3

[0028] Embodiment three: preparation of oral liquid 3 of the present invention

[0029] (1) Weigh 8 grams of knotweed, 13 grams of bean root, 15 grams of escutellaria, 18 grams of windproof, 23 grams of golden buckwheat, 23 grams of eucalyptus leaves, 23 grams of safflower, 5 grams of snake gall, 20 grams of ox gall, and aloe 60 grams, rock sugar 40 grams, ceftiofur sodium 10 grams, levofloxacin 10 grams.

[0030] (2) Add water to decoct the raw materials except ceftiofur sodium and levofloxacin twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1 hour, Combine the two decoctions, filter to obtain the filtrate, concentrate it into an extract with a specific gravity of 1.35, add 85-95% edible glacial acetic acid for extraction, recover the glacial acetic acid and concentrate, dry at 45-50°C to obtain a dry extract 21.32 grams;

[0031] (3) Grinding the dry extract into powder, adding 1...

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Abstract

The invention relates to a veterinary pharmaceutical composition and a preparation method thereof. The veterinary pharmaceutical composition is a vaccine oral solution for curing blue-ear disease, which is composed of the raw materials according to the following parts by weight: 5 to 10 parts of polygonum cuspidatum, 10 to 15 parts of asiatic moonseed rhizome, 12 to 18 parts of erigeron breviscapus, 15 to 10 parts of parsnip, 20 to 25 parts of wild buckwheat rhizome, 15 to 20 parts of eucalypti leaves, 10 to 20 parts of safflower, 2 to 5 parts of snake gallbladder, 10 to 20 parts of ox to gall, 40 to 60 parts of aloe, 25 to 40 parts of rock sugar, 5 to 10 parts of ceftiofur sodium, 5 to 10 parts of levofloxacin. The vaccine oral solution of the invention can be directly used as daily feed for feeding domestic animals or added into water for domestic animals to drink, which can effectively improve immunity of the organisms, disease resistance and anti-stress performance and reduce the rate of being affected by blue-ear disease and enhance the vaccine control effect of curing blue-ear disease.

Description

【Technical field】 [0001] The invention relates to a veterinary pharmaceutical composition and a preparation method thereof. 【Background technique】 [0002] Pig blue-ear disease is characterized by reproductive disorders (abortion, stillbirth, mummified fetus) of pregnant sows and respiratory diseases of pigs of various ages, especially piglets, and has now become one of the main diseases in large-scale pig farms. [0003] The disease was once called "mysterious pig disease", "new pig disease", "porcine epidemic abortion and respiratory syndrome", "porcine reproductive and respiratory syndrome", "blue ear disease", "swine fever", etc. Classify it as a second-class infectious disease. [0004] Pig blue-ear disease is a highly contagious disease that is endemic. Pig blue-ear disease only infects pigs, and pigs of various breeds, ages and uses can be infected, but pregnant sows and piglets within 1 month are most susceptible. Sick pigs and infected pigs are important sources ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/10A61P15/00A61P11/00A61P31/14A61K31/538A61K31/546A61K35/413
Inventor 谢兴荣刘治西唐兆新郭世宁汪连涛王芝武帮勇吴国辉陈胜叶亚多潘永发林仕
Owner 湛江市海科生物科技有限公司
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