Tandem continuous multilevel chiral separation method and device

Abstract

The invention relates to a tandem type continuous multistage chiral splitting method and the device thereof, which belongs to the chiral field. When the chiral splitting is realized by using a solid membrane, the multistage splitting can improve the splitting efficiency, and the problem of realizing the continuous splitting process is the key factor of advancing toward industrialization. The device at least comprises a two-stage membrane filter, two intermediate tanks which are connected in parallel and used for alternately storing permeation liquid are arranged behind each stage membrane filter, and valves are respectively arranged in front of and behind each intermediate tank. The continuous multistage chiral splitting method comprises the following steps: firstly, macro molecule chiralselective agent is added in chiral racemic modification solution, so as to perform chiral recognition reaction, and then a coupling membrane filter realizes splitting. The two intermediate tanks connected in parallel and arranged behind each stage of membrane filter are used for alternately storing the permeation liquid, and simultaneously, before the next stage of membrane filtration splitting is performed, through the alternate switching of the valves of the intermediate tanks, the function of alternate recognition reaction at a specific time can be achieved, thus ensuring the continuity ofthe material supply of the membrane filter system.

Description

technical field [0001] The invention relates to a chiral resolution method and device, in particular to a method for realizing continuous resolution of chiral substances by means of series multistage affinity membrane filtration. Background technique [0002] In recent years, asymmetric chiral compounds have played an extremely critical role in many fields such as medicine, food, spices, and construction, and the "chiral economy" has developed rapidly. The types and quantities of naturally obtained homochiral substances are limited, and asymmetric synthesis technology faces the challenges of low yield, high cost and chiral source constraints. In comparison, chiral resolution has advantages in terms of the type, quantity and cost of obtaining monochiral substances. Chiral resolution, that is, the separation of two enantiomers in a racemic body, has also become a hot topic in the field of international chiral research in recent years. However, because enantiomers have the sa...

AI Technical Summary

Problems solved by technology

Chiral solid membrane resolution can be divided into two categories, one is to directly immobilize the chiral recognition agent on the polymer separation membrane through blending, grafting, immersion and other methods, and then use the diffusion of enantiomers when passing through the solid membrane The separation is achieved by the difference in performance and selectivity. The flux of this type of membrane is usually low, and it is easy to cause a decrease in selectivity during pressurized operation.

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