Compound gelling agent containing clindamycinum
A compound gel, clindamycin technology, applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc. Unequal problems, to achieve the effect of being conducive to detection and quality control, saving preparation time, and simple preparation
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Embodiment 1
[0101] In the first step, first dissolve 0.8 grams of dibutyl hydroxytoluene and 0.2 grams of tretinoin in 240 grams of absolute ethanol, then add 16.0 grams of sodium carboxymethylcellulose, stir at 120 rpm to disperse it evenly, and obtain a component;
[0102] In the second step, 9.6 grams of clindamycin phosphate and 0.4 grams of citric acid were dissolved into 533 grams of distilled water to obtain component b;
[0103] In the third step, component b is slowly added to component a, and added while stirring to obtain a gel.
[0104] Clindamycin Phosphate Assay:
[0105] Take an appropriate amount of the prepared gel (approximately equivalent to 18 mg of clindamycin phosphate), weigh it accurately, put it in a 50 ml conical flask with a stopper, add about 5 ml of mobile phase, shake to disperse, and use the mobile phase to divide Wash into a 25ml volumetric flask, add mobile phase to dilute to the mark, shake well, put in a 15ml centrifuge tube, centrifuge at 4000 rpm per...
Embodiment 2
[0111] In the first step, first dissolve 0.8 grams of dibutyl hydroxytoluene and 0.2 grams of tretinoin in 80 grams of absolute ethanol, then add 16.0 grams of sodium carboxymethylcellulose, stir at 120 rpm to disperse it evenly, and obtain a component;
[0112] In the second step, 9.6 grams of clindamycin phosphate and 0.4 grams of citric acid were dissolved into 693 grams of distilled water to obtain component b;
[0113] In the third step, component b is slowly added to component a, and added while stirring to obtain a gel.
[0114] The detection method of clindamycin phosphate and tretinoin is the same as that in Example 1.
Embodiment 3
[0116] In the first step, 0.8 grams of dibutyl hydroxytoluene and 0.2 grams of tretinoin were dissolved in 400 grams of absolute ethanol, and then 16.0 grams of sodium carboxymethylcellulose was added, stirred at 120 rpm to disperse it evenly, and obtained a component;
[0117] In the second step, 9.6 grams of clindamycin phosphate and 0.4 grams of citric acid are dissolved in 373 grams of distilled water to obtain component b; in the third step, component b is slowly added to component a, while Add while stirring to make a gel.
[0118] The detection method of clindamycin phosphate and tretinoin is the same as that in Example 1.
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