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Tricyclic compounds useful as oxytocin receptor agonists

A compound, mammalian technology, applied in the direction of drug combination, organic chemistry, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2008-10-29
WYETH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The discovery of novel approaches to the treatment and prevention of anxiety and schizophrenia is extremely important because each of these conditions represents a serious concern and the large number of people currently not receiving treatment in a satisfactory manner

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  • Tricyclic compounds useful as oxytocin receptor agonists
  • Tricyclic compounds useful as oxytocin receptor agonists
  • Tricyclic compounds useful as oxytocin receptor agonists

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Abstract

Methods for treating and preventing anxiety, anxiety-related disorders, schizophrenia and schizophrenia-related disorders are described herein wherein said methods comprise the administration of oxytocin receptor agonists. of formula 1, or a pharmaceutically acceptable salt thereof: 1 wherein: G1 is (I) of formula 1, or a pharmaceutically acceptable salt thereof: 2 wherein: G2 is (II).

Description

technical field The present invention relates to the use of non-peptide oxytocin receptor agonists in the treatment of schizophrenia, schizophrenia-related disorders, anxiety and anxiety-related disorders. Background technique Oxytocin (OT) is a nonapeptide that differs from its homotype pituitary neuropeptide, arginine vasopressin (AVP), by two amino acids. OT is mainly synthesized in two subdivisions of hypothalamic neurons, the large cells of the supraoptic nucleus (SON) and paraventricular nucleus (PVN), and the small cells of the PVN. Oxytocinergic neurons of the SON project to the posterior pituitary gland that releases OT from the axon terminals of the basal capillaries into the peripheral circulation. This peripheral release is most closely related to the effects of OT in women during the perinatal period; at this time OT is involved in stimulating uterine smooth muscle contraction during parturition and in triggering the milk ejection reflex in mammary myoepithelia...

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Application Information

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IPC IPC(8): C07D487/04C07D495/14A61K31/5517A61P25/00
CPCC07D495/14A61K31/551C07D487/04A61P25/00A61P25/18A61P25/22A61P43/00A61K31/5517
Inventor 齐亚·拉赫曼林恩·雷斯尼克沙龙·约伊·罗森茨魏希-利普森罗伯特·H·林
Owner WYETH LLC