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Use of probiotics in preparing composition for treating and preventing hand-foot-mouth disease

A technology for hand, foot and mouth disease and probiotics, applied in the field of biological medicine, can solve problems such as unsatisfactory treatment effect, side effects, and impact on children's health, and achieve the effect of preventing the virus from entering the blood

Active Publication Date: 2009-01-07
QINGDAO EASTSEA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug for the treatment of HFMD, and the clinical drugs mainly include antiviral drugs, traditional Chinese medicines and antibacterial drugs, etc., the therapeutic effect is not ideal, and there are side effects, which affect children's health, and treatment and prevention of infection have become medical problems. The drug of the present invention The new use solves this medical problem. It can not only effectively treat hand, foot and mouth disease, but also prevent infection when HFMD is prevalent, and has no side effects, and will not damage children's health. It has great social significance. We hereby apply for a patent for this invention.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0035] Pharmaceutical Preparation Example 1 Preparation of Oral Clostridium Butyricum Live Bacteria Powder

[0036] 1. Preparation of bacterial powder

[0037] Take a tube of Clostridium butyricum strain and dissolve it in a sterilized 100 mL Erlenmeyer flask filled with 10 mL of physiological saline and an appropriate amount of glass beads. Activate in a water bath at 75°C for 10 minutes. Use a 1 mL sterile pipette to draw 1 mL of bacterial suspension and inoculate the container. In a 250mL Erlenmeyer flask with 50mL of expansion medium, place it in a rocking bed with constant temperature shaking (190rpm) at 37°C for 24 hours, transfer to a 2500mL baffle flask containing 450mL of expansion medium, and cultivate for 24 hours at 37°C with constant temperature shaking After the microscopic inspection is free of bacteria, it is transferred to a seed tank containing 4.5L of expansion medium, and anaerobic culture (aeration amount 3:1) for 24 hours. After the microscopic inspection is ...

preparation Embodiment 2

[0040] Pharmaceutical Preparation Example 2 Preparation of Bacillus coagulans viable powder for oral administration

[0041] 1. Preparation of bacterial powder:

[0042] Take a tube of Bacillus coagulans strain, dissolve it in a sterilized 100 mL Erlenmeyer flask containing 10 mL of physiological saline and a suitable amount of glass beads, and activate it in a water bath at 75°C for 10 minutes. Use a 1 mL sterile pipette to absorb 1 mL of bacterial suspension and inoculate the container. In a 250mL Erlenmeyer flask with 50mL of expansion medium, place it in a rocking bed with constant temperature shaking (190rpm) at 37°C for 24 hours, transfer to a 2500mL baffle flask containing 450mL of expansion medium, and cultivate for 24 hours at 37°C with constant temperature shaking After the microscopic inspection is free of bacteria, it is transferred to a seed tank containing 4.5L of amplification medium, and aerobic culture (aeration amount 3:1) for 24 hours. After the microscopic insp...

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PUM

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Abstract

The invention discloses an application of probiotic bacteria in preparing compositions for treating hand-foot-and-mouth disease and preventing infection of hand-foot-and-mouth disease virus, particularly to a new application of probiotic bacteria in preparing medicaments for treating hand-foot-and-mouth disease and preventing infection of hand-foot-and-mouth disease virus. The probiotic bacteria include Clostridium butyricum, Bacillus bifidus, Bacillus coagulans, Lactobacilli sp., Streptococcus sp., Bacillus subtilis, etc.; and the compositions include medicaments, health products and drinks.

Description

Technical field [0001] The present invention relates to a new drug application of probiotics such as Clostridium butyricum, Bacillus coagulans, Bifidobacterium, etc., and specifically relates to probiotics such as Clostridium butyricum, Bacillus coagulans, Bifidobacterium as active ingredients in preparing a combination for treating and preventing hand, foot and mouth disease The application of medicine belongs to the field of biological medicine. Background technique [0002] Probiotics are a class of active microorganisms that play a role by improving the balance of the host's intestinal microflora. They are important physiological bacteria in the human intestine. They can promote the ecological balance of the intestinal microflora and improve the intestinal flora. Structure, promote the proliferation of beneficial bacteria in the intestines, inhibit the growth of harmful bacteria and other important physiological effects. At present, probiotic preparations such as medicines, h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P31/12A61K35/741A61K35/742A61K35/744A61K35/745A61K35/747
Inventor 崔云龙李洪福
Owner QINGDAO EASTSEA PHARMA
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