Mammary gland non-malignant tumor and malignant tumor blood serum special protein and uses thereof
A technology for serum and breast cancer, which is applied in the field of new tumor markers - early serum specific proteins of breast tumors, can solve the problems of distinguishing benign and malignant breast tumors, and achieve excellent results in sensitivity and specificity
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[0028] Example 1:
[0029] 1. Determination of serum specific protein in early breast cancer
[0030] (1) Experimental samples
[0031] 1. Serum of breast cancer patients: 131 cases, all women, with a median age of 52 years, patients who were diagnosed by clinicopathology without surgery, radiotherapy and chemotherapy.
[0032] 2. Serum of patients with benign breast lesions: 91 cases, all female, with a median age of 46 years, patients who were diagnosed by clinicopathology without surgery, radiotherapy and chemotherapy.
[0033] (2) Experimental materials
[0034] 1. Reagents and chips: urea, sodium acetate, acetonitrile, trifluoroacetic acid, DTT, CHAPS were purchased from Sigma in the United States, Sinapinic acid (SPA), weak cation exchanger CM10 were purchased from Ciphergen Biosytems, Inc Fremont , USA company.
[0035] 2. Protein chip reader: protein chip reader (PBSII-C type, Ciphergen Biosystems, Inc. Fremont, USA), according to the principle of laser desorption ion flight...
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[0068] Example 2:
[0069] Specific examples of breast cancer benign and malignant-related serum protein profile classification models can help clinically judge the risk of breast cancer in patients with breast diseases
[0070] 1: Peng Moumou, female, 51 years old, medical record number 80346, the patient came to Fujian Provincial Tumor Hospital in March 2007 due to the discovery of a right breast mass for 2 days. The B-ultrasound showed: 1. The right breast quadrant is upper solid Occupation (prone to right breast cancer) 2. Solid space-occupying in the upper quadrant of the left breast. Molybdenum target showed that the local glands of the right breast were dense, considering the incomplete degeneration of the glands. CEA, CA153, and TPS were all normal. After admission, protein flight mass spectrometry was performed (see Figure 6 , 7), it can be seen that the protein peak intensity of the mass-nucleus ratio 2766 is 14.9, the protein peak intensity of the mass-nucleus ratio 92...
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