Quality control method for yuye qinghuo capsule

A quality control method and fire-clearing technology, which can be used in capsule delivery, medical preparations containing active ingredients, and measuring devices, etc., can solve the problems of poor separation, many identification items, and increased testing costs, and achieve improved effects and simplification. Identification method, the effect of ensuring product quality

Active Publication Date: 2009-02-11
广西厚德药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is found through research that there are still some problems to be solved in this quality control method: the extraction method of the test sample in the determination of the content cannot effectively remove impurities, resulting in the interference of the measurement peak by impurities and poor resolution; there are many identification items, resulting in increased detection costs, long period etc.

Method used

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  • Quality control method for yuye qinghuo capsule
  • Quality control method for yuye qinghuo capsule
  • Quality control method for yuye qinghuo capsule

Examples

Experimental program
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Effect test

preparation example Construction

[0029] The preparation method comparison of need testing solution:

[0030] Method 1 Take 5g of the content of this product, add 50ml of absolute ethanol, let it stand for 30 minutes, heat and reflux for 1 hour, let it cool, filter, evaporate the filtrate to dryness, add 5ml of methanol to the residue to dissolve, add it to a neutral alumina column ( Inner diameter 1cm, length 10cm), elute with the upper layer of toluene-ethyl acetate-formic acid-water (10:7:1.5:1.5), collect the eluate, evaporate to dryness, add 1ml of absolute ethanol to dissolve the residue, and use as The test solution. In the same way, prepare the negative sample solution of Jade Leaf Golden Flower and the negative sample solution of Gardenia.

[0031] Method 2 Take 5g of the content of this product, add 50ml of methanol, heat and reflux for 30 minutes, filter, evaporate the filtrate to dryness, add 20ml of water to dissolve the residue, filter, shake and extract the filtrate twice with ethyl acetate, 20...

Embodiment 1

[0110] 1. Use thin-layer chromatography to qualitatively identify Yuyejinhua and gardenia in the medicine: take 3g of the content of this product, grind it finely, add 50ml of ethanol, heat and reflux for 1.5 hours, filter, evaporate the filtrate to dryness, and dilute the residue with 15ml of water. Heat to dissolve, filter, add on D101 type macroporous resin column (inner diameter 1cm, column height 15cm), elute with 50ml of water, then elution with 50ml of 20% ethanol, collect 20% ethanol eluate, evaporate to dryness, Add 1ml of methanol to the residue to dissolve it as the test solution. Take another 4g of the reference herbal medicine Jade Leaf Golden Flower, add 50ml of water, decoct for 20 minutes, filter, concentrate the filtrate to 1ml, add 30ml of absolute ethanol, stir well, filter, evaporate the filtrate to dryness, add 1ml of methanol to the residue to dissolve, and use it as Jade Leaf Golden Flower Control drug solution. Then take 1 g of gardenia reference medic...

Embodiment 2

[0118] 1. Carry out qualitative identification to Jade leaf golden flower and gardenia in medicine with thin-layer chromatography:

[0119] Take 3g of the content of this product, grind it finely, add 50ml of ethanol, heat and reflux for 1 hour, filter, evaporate the filtrate to dryness, dissolve the residue with 20ml of water, filter, add to D 101 Type macroporous resin column (inner diameter 1cm, column height 18cm), eluted with 100ml of water, then eluted with 100ml of 30% ethanol, collected the 30% ethanol eluate, evaporated to dryness, and added 1ml of methanol to the residue to dissolve, used as test product solution. Take another 4g of the reference herbal medicine of Jade Leaf Golden Flower, add 100ml of water, decoct for 30 minutes, filter, concentrate the filtrate to 2ml, add 50ml of absolute ethanol, stir well, filter, evaporate the filtrate to dryness, add 1ml of methanol to the residue to dissolve, and make Jade Leaf Golden Flower Control drug solution. Then tak...

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Abstract

The invention provides a quality control method for Yuyeqinghuo capsule. The thin layer chromatography identification can be simultaneously performed for Mussaenda pubescen and gardenia, the thin layer chromatography identification can be performed for yerbadetajo, and the content of the characteristic components of green chiretta such as andrographolide and the dehydrated andrographolide can be detected. The quality control method for the Yuyeqinghuo capsule has the advantages of environmental protection, good separation degree of content detection method, simplified identification method and strong operability.

Description

technical field [0001] The invention belongs to the quality control of traditional Chinese medicines, in particular to a quality control method for Yuye Qinghuo capsules. Background technique [0002] Yuye Qinghuo Capsule is a modified product of Yuye Qinghuo Tablet. The original tablet prescription is recorded on page 144 of "National Standards for Local Standards of Chinese Proprietary Medicines" (Ophthalmology, Otorhinolaryngology, and Dermatology) and the standard code is WS-11093 (ZD-1093)-2002. , for sore throat, violent silence, acute pharyngitis belongs to wind-heat syndrome. It has been used clinically for many years and has achieved satisfactory results. The prescription of Yuye Qinghuo Capsule is the same as that of the tablet. It is made from Chinese herbal medicines Jade Yejinhua 400g, Andrographis paniculata 300g, Gardenia 100g, Eclipta 150g, and Indochina 100g according to the following process: 100g of Andrographis paniculata and Gardenia are crushed into f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N33/15A61K36/744A61K9/48A61P11/04
Inventor 唐弟光陈晓军李品莫少红梁山丹蒙华英梁霞
Owner 广西厚德药业有限公司
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