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Sticking tablet for curing mouth ulcer using mometasone furoate as active component

A technology of oral ulcers and active ingredients, applied in the field of adhesive tablets for the treatment of oral ulcers with mometasone furoate as the active ingredient, to achieve the effect of overcoming potential harm

Active Publication Date: 2009-02-25
TIANJIN PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And above-mentioned several kinds of plasticizers are mainly used in the purposes such as the packaging of food and drug in the prior art, and do not use it for the report of plasticizer in drug coating

Method used

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  • Sticking tablet for curing mouth ulcer using mometasone furoate as active component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] paste sheet

[0025] Mometasone furoate 0.1g

[0026] Carbomer 10g

[0027] Dextrin 30g

[0028] Magnesium stearate 0.03g

[0029] The protective layer

[0030] 100-55 4g

[0031] Titanium dioxide 1g

[0032] Yellow Iron Oxide 1g

[0033] Acetyl tributyl citrate (ATBC) 0.8g

[0034] Preparation Process:

[0035] Dissolve mometasone furoate with 5ml of absolute ethanol, add the solution of the above active ingredients into dextrin passed through a 100-mesh sieve, mix well, then granulate through a 30-mesh sieve, dry at 60°C, and then sieve through a 40-mesh sieve Add carbopol and magnesium stearate passed through a 100-mesh sieve, mix thoroughly, and press into tablets with a flat punch with a diameter of 6 mm to obtain 1,000 tablets, each containing 0.10 mg of mometasone furoate. the prescribed amount 100-55 is dissolved in 95ml of 95% ethanol, and the prescribed amount of ATBC, titanium dioxide, and yellow iron oxide is added, and each tablet weighs abou...

Embodiment 2

[0037] For the formula of Example 1, the active ingredient is changed to mometasone furoate 0.2g, the plasticizer is changed to tributyl citrate (TBC) and other preparation processes are the same as in Example 1

Embodiment 3

[0039] paste sheet

[0040] Mometasone furoate 0.5g

[0041] Carbomer 5g

[0042] Polyvinylpyrrolidone (PVP) 3g

[0043] Dextrin 30g

[0044] Magnesium stearate 0.05g

[0045] The protective layer

[0046] 100-55 4g

[0047] Titanium dioxide 0.5g

[0048] Trihexyl citrate (THC) 0.8g

[0049] Preparation Process:

[0050] Dissolve mometasone furoate with an appropriate amount of absolute ethanol, add the solution of the above active ingredients to dextrin passed through a 100-mesh sieve, mix well, then granulate through a 30-mesh sieve, dry at 60°C, and pass through a 40-mesh sieve Add carbomer, PVP, and magnesium stearate through a 100-mesh sieve and mix thoroughly, then press a flat punch with a diameter of 6mm to obtain 1000 tablets, containing 0.5mg of methylprednisolone. 100-55 was dissolved with 95ml of 95% ethanol, added THC and titanium dioxide in the prescribed amount, ground evenly, sprayed evenly on the surface of the tablet with a film spraying machine...

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PUM

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Abstract

The invention relates to an oral sticking tablet used for treating human or animal dental ulcer; the oral sticking tablet consists of an adhesive layer containing active components and a water insoluble protective layer; the inactive component containing in the adhesive layer consists of a filling agent, an adhesive sustained-released agent and a lubricant that are applicable to tablet, and the water insoluble protective layer consists of polyacrylic acid resin and / or ethyl cellulose which can be used as protective coatings and a plasticizer, and the active component is momestasone furoate.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for treating oral ulcers in humans or mammals and its application, in particular to an oral adhesive tablet Background technique: [0002] Oral ulcer is also called recurrent aphtha, is commonly called as aphthous ulcer, is a kind of common oral cavity membrane disease. Recurrent oral ulcers refer specifically to a class of unexplained, recurrent but self-limited, isolated, round or oval ulcers. It is also called recurrent aphthous ulcer (Aphthous is the meaning of "burning and ulceration" in Greek) or recurrent aphthous ulcer. Clinically, it can be divided into three types according to the size, depth and number of ulcers: recurrent mild oral ulcers, recurrent stomatitis ulcers and recurrent necrotizing mucosal periadenitis. [0003] Recurrent oral ulcers are one of the most common diseases in oral mucosal diseases. In people's life, there are almost no oral ulcers that do not occur, but some pe...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K9/70A61K47/32A61K47/34A61K47/38A61K47/40A61P1/02
Inventor 李静张其婉李宏铃马晓勇陈松胡筱芸
Owner TIANJIN PHARMA GROUP CORP
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