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Biomarkers for endometrial proliferation

An endometrial and mid-uterine technology, applied in the field of biomarkers of endometrial proliferation, can solve problems such as effective treatment and prevention of diseases related to endometrial proliferation that have not been established

Inactive Publication Date: 2009-05-06
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, until now no effective treatment and / or prevention of diseases associated with endometrial proliferation has been established

Method used

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  • Biomarkers for endometrial proliferation
  • Biomarkers for endometrial proliferation
  • Biomarkers for endometrial proliferation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0102] Gene Expression Analysis

[0103] Materials and methods

[0104] animal

[0105] The ovariectomized (OVX) macaque (Macaca fascicularis) was used as a model of estrogen deficiency, which has proven to be a useful model for predicting the outcome of human clinical trials of estrogen and SERMs. The study was carried out in accordance with the Animal Health regulation, Council Directive No. 86 / 609 / EEC on laws, regulations or regulations relating to the protection of animals used for experimental or other scientific purposes . Animals were acclimatized to the treatment facility for at least 14 days prior to initiation of treatment. Animals received water and approximately 180 g of OWM pelleted food (Dietex France, SDS, Saint Gratien, France) ad libitum daily for at least 1 hour after dosing, except on the last day of treatment where animals were fasted. Additionally, each animal received two servings of fruit or vegetables per day. Sexually mature female cynomolgus monk...

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PUM

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Abstract

The present invention relates to a method for qualitatively and / or quantitatively determining endometrial proliferation in a sample. The invention also relates to compositions or kits and arrays for qualitatively and / or quantitatively determining endometrial proliferation. Further, the invention relates to a method for the diagnosis of a disorder that is associated with a dysfunction of endometrial proliferation or a predisposition therefore in a subject.

Description

field of invention [0001] The present invention relates to a method for the qualitative and / or quantitative determination of endometrial proliferation in a sample. The invention also relates to compositions or kits and arrays for qualitative and / or quantitative determination of endometrial proliferation. In addition, the present invention relates to methods for diagnosing a disorder associated with abnormal endometrial proliferative function or a predisposition thereto in a subject. Background of the invention [0002] The endometrium is the lining of the uterine cavity. Under the influence of ovarian hormones, necessary anatomical and functional changes occur in the endometrium. [0003] Thus, under physiological conditions, the endometrium thickens under hormonal control and continues throughout a woman's reproductive cycle, shedding during menstruation and regenerating every menstrual cycle if pregnancy does not occur. Until the fifth day of the menstrual cycle, the en...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/574C12Q1/68A61K38/00A61K48/00
CPCG01N33/57442C12Q1/6886C12Q2600/136G01N33/689A61P15/00A61P15/08A61P35/00G01N33/57407
Inventor M·博巴迪拉S-D·希布A·科迪尔
Owner NOVARTIS AG