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Partial compound erythrocin zinc acetate gelling agent and preparation method thereof

The technology of compound erythromycin and zinc gel, which is applied in the field of medicine, can solve the problems of inconvenience of clinical use of compound erythromycin and zinc acetate solution, and achieves low incidence of local adverse reactions on the skin, easy acceptance, and no contamination to clothing. Effect

Active Publication Date: 2009-09-30
TAIJI GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The problem to be solved by the present invention is that the existing compound erythromycin zinc acetate solution is inconvenient in clinical use, and a kind of gel agent with simple preparation method, convenient use and good drug compliance of patients is provided, and the gel agent is stable High sensitivity, skin comfort and skin permeability and good clinical effect

Method used

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  • Partial compound erythrocin zinc acetate gelling agent and preparation method thereof
  • Partial compound erythrocin zinc acetate gelling agent and preparation method thereof
  • Partial compound erythrocin zinc acetate gelling agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Erythromycin 40g

[0029] Zinc acetate 12g

[0030] Glycerin 120g

[0031] Hypromellose 12g

[0032] Triethanolamine 60g

[0033] Add ethanol to 1000g

[0034] Preparation Process:

[0035] (1) adding hydroxypropyl cellulose to 500g ethanol to fully swell;

[0036] (2) The erythromycin, zinc acetate, glycerin, triethanolamine of above-mentioned proportioning are added in the ethanol of remaining amount, stir and dissolve;

[0037] (3) Add (2) solution into (1) solution and stir evenly to form a gel.

Embodiment 2

[0039] Erythromycin 40g

[0040] Zinc acetate 12g

[0041] Hypromellose 16g

[0042] Glycerin 80g

[0043] Triethanolamine 80g

[0044] Add ethanol to 1000g

[0045] Preparation Process:

[0046] (1) adding hypromellose to 700g ethanol to fully swell;

[0047] (2) The erythromycin, zinc acetate, glycerin, triethanolamine of above-mentioned proportioning are added in the ethanol of remaining amount, stir and dissolve;

[0048] (3) Add (2) solution into (1) solution and stir evenly to form a gel.

Embodiment 3

[0050] Erythromycin 30g

[0051] Zinc acetate 12g

[0052] Glycerin 50g

[0053] Hypromellose 18g

[0054] Triethanolamine 60g

[0055] Benzalkonium Bromide 10.0g

[0056] Add ethanol to 1000g

[0057] Preparation Process:

[0058] (1) Hypromellose is added to fully swell in 750g ethanol;

[0059] (2) Add the erythromycin, zinc acetate, glycerol and triethanolamine of the above proportioning ratio to the ethanol of the remaining amount, stir and dissolve, then add benzalkonium bromide and stir evenly;

[0060] (3) Add (2) solution into (1) solution and stir evenly to form a gel.

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Abstract

The invention belongs to the technical field of medicines, in particular to a partial gelling agent and a preparation method thereof. Erythrocin and zinc acetate are used as active ingredients so that the partial gelling comprises the active ingredients of the erythrocin and the zinc acetate as well as an aqueous gel base, a stabilizing agent and ethanol and is clinically used for curing common acne. The gelling agent has simple preparation technology, high stability and good skin comfort, percutaneous permeation and clinic effect and provides a new choice for clinically curing the acne.

Description

Technical field: [0001] The invention belongs to the field of medicine, and relates to a local compound erythromycin zinc acetate gel, which is clinically used for treating acne. Background technique: [0002] Acne is a chronic pilosebaceous gland inflammatory skin disease. The cause of the disease is related to the strong secretion of sebaceous glands, the increase of free fatty acids on the skin surface, and the infection of Propionibacterium acnes. Acne is a multifactorial pilosebaceous disease, including hypersecretion of sebum, hyperkeratosis of follicles, proliferation of Propionibacterium acnes, and excessive immune response. In addition, it is also related to genetic and psychological factors. During treatment, the choice of regimen should be aimed at the pathogenic link as much as possible. Its clinical manifestations are mainly acne, papules, pustules, nodules and cysts on the face, and individual patients may form sunken or hypertrophic scars, which seriously af...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/19A61K47/38A61K47/32A61K9/10A61P17/10
Inventor 谢晓燕张自强包玉胜朱丽君晁阳李战李纬曹芳
Owner TAIJI GROUP
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