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Coproduction process for extracting various bioactivators from pig placenta

A bioactive substance and pig placenta technology, applied in biochemical equipment and methods, anti-animal/human immunoglobulin, peptide preparation methods, etc., can solve problems such as shortage of supply, solve emission problems, reduce production costs, collection of handy effects

Active Publication Date: 2009-09-30
ZHENGZHOU NUBLION BIOTECH
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Problems solved by technology

At the same time, immunoglobulin can also be used as a feed additive for young animals, especially in intensive breeding bases. Applying immunoglobulin to early weaned young animals can reduce diseases of young animals and promote growth and development. Currently, the animal feed additive market is in short supply.

Method used

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  • Coproduction process for extracting various bioactivators from pig placenta

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Embodiment Construction

[0038] The specific operation steps of the present invention will be further described below in conjunction with the accompanying drawings:

[0039] 1. Collect the fresh placenta (including piglet blood) from the sow within 24 hours after delivery and weigh it. Cut the fetal membranes and umbilical cord, add an equal weight volume of 2% sodium chloride water to soak for about 1 hour, crush with a meat grinder, then soak for more than 1 hour, coarse filter (20 mesh), and collect the filtrate (I) And filter residue (I).

[0040] 2. Centrifuge the filtrate (3000 rpm) for 20 minutes, and collect the supernatant (I) and the red precipitate. Add an equal volume of deionized water to the red precipitate, stir for 30 minutes to fully hemolyze the red blood cells, then add ammonium sulfate by volume to 50% saturation, stir for 30 minutes, stand for 2 hours, and centrifuge. Measure the volume of the centrifugal supernatant, add 0.15 times the volume of ethanol, 0.08 times the volume of chlo...

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Abstract

The invention provides a coproduction process for extracting various bioactivators from pig placenta, which comprises the following steps: taking the pig placenta (containing farrowing blood) as a raw material, utilizing components rich in the raw material such as immune globulin (Ig), immunocompetent peptide, superoxide dismutase (SOD), lipopolysaccharide, placental protein and the like, and applying modern biochemistry technology and biological integration technology such as salting in, salting out, chromatography, ultra-filtration and the like according to different structures, molecular weights, isoelectric points, physical and chemical properties, biological activities of the components to make the coproduction process suitable for industrial production. Therefore, in the same flow of the production process, the effective components in the pig placenta with market development value can be produced, namely five products of the immune globulin, the immunocompetent peptide, the superoxide dismutase, the lipopolysaccharide and the placental protein. The process combines the conventional and modern processes, produces various products through coproduction, and not only makes full use of placenta resources to change the waste into the treasure, does not discharge waste liquid and prevents the environment, but also can greatly reduce the production cost and improve the economic benefit.

Description

Technical field [0001] The invention relates to the field of biotechnology, in particular to a combined production process for the comprehensive utilization of pig placenta (including hematogenesis). It uses pig placenta as the main raw material and applies modern biological process integration technology to produce immunity in the same production process. There are five series of products including globulin (Ig), immunologically active peptides, superoxide dismutase (SOD), lipopolysaccharide, and placental protein, which can be widely used in medicine, health care, daily chemical industry and animal husbandry. Background technique [0002] Humans have a long history of using the placenta. About 400 years ago, Li Shizhen, in his "Compendium of Materia Medica", which collected the great achievements of ancient and modern Chinese medicine, believed that the placenta of humans, sheep, pigs, cattle and other mammals could be used as medicine, and named the placenta "Purple River Cart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N9/08C07K16/18C07K14/47C07K1/14C12P21/06C08B37/00
Inventor 常功张俊英王景仙
Owner ZHENGZHOU NUBLION BIOTECH
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