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Interface device for coupling capillary electrophoresis with inductively coupled plasma mass spectrograph and use method thereof

A technology of capillary electrophoresis and inductive coupling, which is applied in the field of chemical analysis, can solve the problems of unable to provide very stable electrical connection, unable to solve the problem of peak broadening, and no commercial interface, etc., to achieve fast measurement speed, high sensitivity, and improved sensitivity. Effect

Inactive Publication Date: 2009-11-11
FUZHOU UNIVERSITY
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  • Abstract
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  • Application Information

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Problems solved by technology

The combination of capillary electrophoresis and mass spectrometry has been reported, however, there is no commercial interface
The publicly published cross-shaped and simple-shaped capillary electrophoresis instrument and ICP-MS interface can not solve the problem of peak broadening caused by the drag caused by the connection of ICP-MS and excessive dilution makes the sensitivity lower problems, and at the same time cannot provide a very stable electrical connection

Method used

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  • Interface device for coupling capillary electrophoresis with inductively coupled plasma mass spectrograph and use method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] When the sample is separated in the capillary electrophoresis instrument, the current controller controls the rotation of the cleaning solution peristaltic pump 4 and stops the sample solution peristaltic pump 5, which will not affect the separation of the capillary electrophoresis instrument; when a certain component in the sample is separated, The current controller controls the cleaning solution peristaltic pump 4 to stop, and rotates the sample solution peristaltic pump 5 to send the components to be measured into the inductively coupled plasma mass spectrometer for measurement. Since the peristaltic pump 4 has stopped and no auxiliary liquid enters, the inductively coupled plasma mass spectrometer The sensitivity of the instrument is not affected, and the detection limits of different substance concentrations in the collection and injection mode are shown in Table 1.

[0013] Table 1

[0014] Analyte

Embodiment 2

[0016] When the sample is separated in the capillary electrophoresis instrument, the current controller controls the cleaning solution peristaltic pump 4 and the sample solution peristaltic pump 5 to rotate simultaneously at different speeds, and when a component in the sample is separated and flows out of the capillary, it is immediately sent into the inductively coupled plasma Mass spectrometry is used for measurement, the measurement speed is very fast and the dead volume is small, so as to realize continuous sample injection. The detection limits of different substance concentrations in the continuous injection mode are shown in Table 2.

[0017] Table 2

[0018]

[0019] The pump speed ratio of embodiment 1 and 2 is as follows table 3:

[0020] table 3

[0021]

[0022] The speed of pump 5 is basically fixed at 12 μL / min, and the speed of pump 4 is related to the properties of the analyte, and some adjustments must be made according to the properties...

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Abstract

The invention provides an interface device for coupling a capillary electrophoresis with an inductively coupled plasma mass spectrograph and use method thereof. The interface device is characterized by comprising a stainless steel capillary pipe, a sample solution peristaltic pump and a T-shaped capillary pipe, wherein the stainless steel capillary pipe is connected with a high voltage source, aninlet on the left end thereof is respectively connected with the capillary electrophoresis and a miniflow and sheath flow pipe, and the output end of the stainless steel capillary pipe is connected with the input end of the T-shaped capillary pipe by the sample solution peristaltic pump; the output end of the T-shaped capillary pipe is connected in the inductively coupled plasma mass spectrograph;and the lower end of the T-shaped capillary pipe is connected with the output end of a wash solution peristaltic pump, and the modes of continuous sample introduction and collective sample introduction can be adopted during test. The device has simple structure and solves the problem of hard coupling of the capillary electrophoresis and the inductively coupled plasma mass spectrograph.

Description

technical field [0001] The invention relates to the field of chemical analysis, and more specifically relates to an interface device for coupling capillary electrophoresis and inductively coupled plasma mass spectrometer and a method for using the same. Background technique [0002] Inductively coupled plasma mass spectrometry (ICP-MS) is a new analytical testing technology developed in the 1980s. It combines the high temperature (7000K) ionization characteristics of ICP-MS with the advantages of sensitive and fast scanning of quadrupole mass spectrometer with unique interface technology to form a new type of element and isotope analysis technology, which can analyze most elements on the earth . The combination of capillary electrophoresis and mass spectrometry has been reported, but there is no commercial interface at present. The publicly published cross-shaped and simple-shaped capillary electrophoresis instrument and ICP-MS interface can not solve the problem of peak b...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N27/447B01D57/02G01N27/626
Inventor 付凤富杨桂娣许锦华徐两军
Owner FUZHOU UNIVERSITY
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