Micro-fluidic chip special for diagnosing syphilis by aid of organic conductor material technology

Abstract

The invention relates to a micro-fluidic chip special for diagnosing syphilis by aid of organic conductor material technology, belonging to the field of analytical testing. One of the improved purposes of the related therapy is to rapidly and cheaply diagnose the syphilis; the invention provides a micro-fluidic chip aiming at the purpose. The technical proposal is that: the chip comprises four branch pipes which are mutually connected in parallel; four fibrous working electrodes are installed in the four branch pipes; the fibrous working electrodes are composed by fibrous electrodes and golden coating sensitive films adhered on the fibrous electrodes and embedded with syphilis-specific antigen; each golden coating sensitive film at surface of the four fibrous working electrodes is respectively embedded with four different syphilis-specific antigen substances; the four antigen substances are respectively syphilis-specific antigen TP0684, TP0453, TP0821 and TP0319. The body materials of the fibrous working electrodes are pyrolysis conductive macromolecule materials. The chip in the invention has low cost and multiple channels.

Description

technical field [0001] The invention relates to a special microfluidic chip for syphilis diagnosis by means of organic conductor material technology, which belongs to the field of analysis and testing. Background technique [0002] Syphilis is a sexually transmitted disease (STD) caused by Treponema pallidum (TP). Treponema pallidum only infects humans under natural circumstances, and humans are the only source of infection for syphilis, mainly through sexual contact. It can also be transmitted vertically through the placenta, causing congenital syphilis in the fetus. A small number of people can also be infected by blood transfusion. Since the 1980s, syphilis has revived again in my country. According to statistics from the National Center for STD Control, the annual growth rate of the incidence of syphilis in my country has reached 52.7%, and the incidence of congenital syphilis and neurosyphilis has increased significantly, and there is a gradual upward trend in the wor...

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Problems solved by technology

(4) At present, microfluidic sensors are mostly based on optical detection systems. The instruments are expensive and bulky, and full integration is difficult. Moreover, the detection cost is high, which limits its promotion.

[0006] At present, in the field of microfluidic chip technology, the related technologies and methods of using multiple specific antigens of syphilis to simultaneously detect and rapidly diagnose multiple syphilis antibodies have not been reported; on the other hand, most of the existing technologies in this field use expensive Gold is used as the core component of the test sensor, that is, the basic material of the working electrode. The use of this expensive metal material increases the manufacturing cost of related chips. In view of the known dangers of related infectious diseases detected by chips, related diseases There are unsafe factors in the gold recovery work in the detection microfluidic chip, which will increase the difficulty of the gold recovery work and increase the cost of the gold recovery operation, which in turn may cause valuable economical considerations. The loss of resource gold, obviously, this technical flaw also needs to be eliminated

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