Microdevice and method for transdermal delivery and sampling of active substances
A technology of micro-device and skin, applied in the field of micro-device for transdermal delivery of active substances, which can solve the problem of slow onset of action
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Examples
Embodiment 1
[0138] Example 1. Delivery of docetaxel using a combination of microneedles and soft liposomal nanoparticles.
[0139] figure 2 and image 3 The effectiveness of transdermal delivery of agents of the present invention is demonstrated. exist figure 2 and image 3 In the tests shown, areas of skin were pretreated with the microneedles described above. Preparations of fluorescently labeled albumin (66,000 molecular weight) were then applied and they were successfully transported through the skin ( image 3 ). The pores formed by the microneedles did not close completely for 72 hours after application of the microneedles. figure 2 Penetration (%) of docetaxel in liposomes with and without microneedles is shown.
Embodiment 2
[0140] Example 2. Combination delivery of interferon with microneedles.
[0141] Figure 4 Interferon was shown to be delivered via different methods. The effectiveness of various delivery methods was assessed by measuring interferon activity: (a) microneedles with wet interferon gel on the microneedles, (b) interferon gel on skin pretreated with microneedles Microneedles of the patch, (c) subcutaneous injection, and (d) wet interferon gel without microneedles as control samples.
[0142] Figure 5 Shown to deliver interferon with a dry formulation. Such as Figure 5 As shown, the delivery rate drops significantly when the patch is dried.
[0143] all in all, Figure 4 and Figure 5 Shown to be less effective in delivering interferon with dry patches than with wet patches.
Embodiment 3
[0144] Example 3. Measuring penetration through the skin
[0145] Figure 6 The confocal laser micrographs were obtained by applying the microneedle array on the skin with an applicator and then allowing the nanoparticles containing red fluorescent rhodamine B to diffuse through the skin for less than 30 minutes. These photos are skin sections at different depths. The depth is marked at the top of each photo. From these photos it can be clearly seen that a high concentration of fluorescent probes can be found at a depth of 10um to 100um from the skin surface.
[0146] Another example of penetration measurement is shown in Figure 7 . Fluorescently labeled insulin was in a donor reservoir, while the recipient reservoir was devoid of insulin. The two reservoirs are separated by a skin barrier pretreated with nanotubes created by microneedles. The intensity of fluorescence on the receiving reservoir side is directly proportional to the amount of insulin that has penetrated ...
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Abstract
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