Combination of a glucocorticoid and a ss-cyclodextrin conjugated vitamin a derivate complex

A technology of glucocorticoid and cyclodextrin, which is applied in the field of preventing, reducing or eliminating skin atrophy caused by glucocorticoid treatment, and can solve side effects and other problems

Inactive Publication Date: 2009-12-30
PHARMA MEDICO RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the compound does have side effects

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  • Combination of a glucocorticoid and a ss-cyclodextrin conjugated vitamin a derivate complex
  • Combination of a glucocorticoid and a ss-cyclodextrin conjugated vitamin a derivate complex

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Embodiment Construction

[0035] In a first embodiment of the present invention, it is possible to prevent, reduce or eliminate skin atrophy induced by GC treatment by combining a glucocorticoid and a β-cyclodextrin-conjugated vitamin A derivative complex, thus A combination drug of a glucocorticoid and a β-cyclodextrin-conjugated vitamin A derivative complex is provided. Also provided are pharmaceutical compositions comprising a complex of a glucocorticoid and a [beta]-cyclodextrin-conjugated vitamin A derivative.

[0036] Vitamin A acid is also known as retinoic acid (3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8- nonatetonic acid). Retinoic acid is a physiological metabolite of retinol, and the product is mainly all-trans. Preferred vitamin A derivatives according to the invention are retinyl esters, especially retinyl palmitate.

[0037] The aforementioned vitamin A derivative forms a complex with β-cyclodextrin. Cyclodextrins are natural clathrates. They consist of uniform cyclic...

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Abstract

The present invention is related to a pharmaceutical combination of a glucocorticoid and a Beta-cyclodextrin conjugated vitamin A derivative complex as well as a pharmaceutical composition comprising the same. The combination and the composition of the invention can be used for reducing or eliminating skin atrophy induced by treatment with glucocorticoids (GC). Also comprised is a method for reducing or eliminating skin atrophy induced by GC treatment. Furthermore the invention concerns a kit comprising a glucocorticoid and a Beta-cyclodextrin conjugated vitamin A derivative complex.

Description

field of invention [0001] The present invention relates to a combination drug of glucocorticoid and β-cyclodextrin conjugated vitamin A derivative complex; and a pharmaceutical composition containing the combination drug. The combination medicine and composition can be used to prevent, reduce or eliminate skin atrophy caused by glucocorticoid treatment. The present invention also provides methods of preventing, reducing or eliminating skin atrophy caused by glucocorticoid treatment. In addition, the present invention also relates to a kit comprising a complex of a glucocorticoid and a [beta]-cyclodextrin-conjugated vitamin A derivative. Background of the invention [0002] The skin is the largest organ of the human body and is extremely complex due to its many functions. It should protect the body from toxic substances, which means it must have a strong barrier function. It should be able to withstand different types of trauma, and if the skin is injured, it must be able ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K31/07A61K31/724A61P17/00
CPCA61K31/07A61K31/724A61K31/56A61P17/00A61K2300/00
Inventor J·瓦德斯坦E·汤姆
Owner PHARMA MEDICO RES
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