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Application of scutellarin extract in preparation medicaments for preventing and treating pulmonary fibrosis

A technology for pulmonary fibrosis and preparation of drugs, which is applied in the field of medicine to achieve the effect of reducing lung coefficient, definite curative effect and low price

Inactive Publication Date: 2010-06-02
苏州中药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the fact that baicalein extract has many pharmacological effects such as anti-inflammation, anti-oxidation, scavenging oxygen free radicals, antibacterial and anti-virus, and there is no report on the application of baicalein extract to prevent and treat pulmonary fibrosis, the inventors studied Whether baicalein extract can prevent and treat BLM-induced pulmonary fibrosis mouse model

Method used

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  • Application of scutellarin extract in preparation medicaments for preventing and treating pulmonary fibrosis
  • Application of scutellarin extract in preparation medicaments for preventing and treating pulmonary fibrosis
  • Application of scutellarin extract in preparation medicaments for preventing and treating pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1.1 Purpose of the experiment: To observe the effect of baicalein extract on body weight and lung coefficient of BLM-induced pulmonary fibrosis mice

[0038] 1.2 Experimental materials

[0039] Experimental animals: 90 Kunming mice, both male and female, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Experimental animal production license number SCXK (Su) 2007-0007, experimental animal use license SYXK (Su) 2007-0035. During the experiment, the temperature of the breeding room was 20±3.2°C, and the relative humidity was 55±10%.

[0040] Test drug: baicalein extract, baicalein content ≥ 50%, brownish-yellow crystals, lot number: 090429, extracted from Scutellaria baicalensis root by the phytochemical laboratory of our institute, and stored in a refrigerator at 4°C. Add 5% carboxymethylcellulose sodium (CMC-Na) to make a suspension before use; bleomycin A5 (BLM A5), white freeze-dried powder, 15mg / bottle, Nippon Kayaku...

Embodiment 2

[0057] 2.1 Purpose of the experiment: To observe the effect of baicalein extract on serum SOD activity, MDA content and ability to inhibit OH in BLM-induced pulmonary fibrosis mice

[0058] 2.2 Experimental materials

[0059] Experimental animals: 90 Kunming mice, both male and female, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. The experimental animal production license number is SCXK (Su) 2007-0007, and the experimental animal use license number is SYXK (Su) 2007-0035. During the experiment, the temperature of the breeding room was 20±3.2°C, and the relative humidity was 55±10%.

[0060]Test drug: baicalein extract, baicalein content ≥ 50%, brownish-yellow crystals, lot number: 090429, extracted from Scutellaria baicalensis root by the phytochemical laboratory of our institute, and stored in a refrigerator at 4°C. Add 5% carboxymethylcellulose sodium (CMC-Na) to make a suspension before use; bleomycin A5 (BLM A5), whit...

Embodiment 3

[0079] 3.1 Purpose of the experiment: To observe the effect of baicalein extract on SOD activity, MDA content and T-AOC in lung tissue of mice with pulmonary fibrosis induced by BLM

[0080] 3.2 Experimental materials

[0081] Experimental animals: 90 Kunming mice, both male and female, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. The experimental animal production license number is SCXK (Su) 2007-0007, and the experimental animal use license number is SYXK (Su) 2007-0035. During the experiment, the temperature of the breeding room was 20±3.2°C, and the relative humidity was 55±10%.

[0082] Test drug: baicalein extract, baicalein content ≥ 50%, brownish-yellow crystals, lot number: 090429, extracted from Scutellaria baicalensis root by the phytochemical laboratory of our institute, and stored in a refrigerator at 4°C. Add 5% carboxymethylcellulose sodium (CMC-Na) to make a suspension before use; bleomycin A5 (BLM A5), wh...

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Abstract

The invention discloses application of scutellarin extract in the preparation of medicaments for preventing and treating pulmonary fibrosis. An animal model of mouse pulmonary fibrosis is copied by dripping Bleomycin (BLM) in the trachea, and the scutellarin extract is selected to be used as treating medicament for the first time. The study of the influence of the scutellarin extract on the biochemical indexes and pathological change relative to the lung tissue and blood serum of an animal with pulmonary fibrosis and the observation of the therapeutic action of the scutellarin extract on an animal model with pulmonary fibrosis provide experimental basis for the scutellarin extract to treat pulmonary fibrosis. The scutellarin extract with effective treatment amount can be combined with pharmaceutically accepted carriers for preparing medicaments.

Description

technical field [0001] The present invention relates to the application of an active ingredient extract in a traditional Chinese medicine in the preparation of a drug for preventing and treating pulmonary fibrosis, specifically the application of the baicalein extract in the traditional Chinese medicine Scutellaria baicalensis in the preparation of a drug for preventing and / or treating pulmonary fibrosis, belonging to field of medical technology. Background technique [0002] The traditional Chinese medicine Scutellaria baicalensis, also known as camellia root, scutellaria baicalensis tea, and golden bar root, is the dry root of the perennial herb Scutellaria baicalensis Georgi of the Labiatae family (Labiatae). Chinese medicine, with a long history of medicinal use, has been recorded in successive dynasties of herbal medicines, and is one of the bulk of Chinese herbal medicines in my country. It is cold in nature and bitter in taste, and returns to the lung, gallbladder, st...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K36/539A61P11/00
Inventor 顾振纶蒋小岗高燕郭次仪周忠继
Owner 苏州中药研究所有限公司
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