Method for extracting ajmaline from devilpepper waste liquor

Abstract

The invention discloses a method for extracting ajmaline from devilpepper waste liquor. The ajmaline is obtained by extracting a raffinate of devilpepper with extracted reserpine and adopting methods, i.e. stepped extraction, decoloration sedimentation, washing crystallization, and the like, i.e. the ajmaline is separated when the reserpine is produced by using devilpepper medicinal materials, thereby realizing the effective utilization of plant resources, solving the problem that the reserpine and the ajmaline are produced at the same time by using the devilpepper, enhancing the utility ratio of resources, increasing the types of products and generating new profit growth points. The invention adopts simple and easy extracting method and refining method, can conveniently and fast obtain the ajmaline according with the specifications of a pharmacopeia and is suitable for large-scale production.

Description

technical field

[0001] The invention belongs to the field of separation and purification of natural medicines, in particular to a method for extracting ayimalin from waste liquid of Rauvolwolfia. Background technique

[0002] Rauwolfia contains a variety of alkaloids with pharmacological activity, and more than 100 kinds have been isolated. The alkaloids with high content are reserpine, ayimarin, serpentine and yohimbine, among which the main clinical effect of reserpine is to lower blood pressure, and the content of reserpine in Rauvolwolfia is generally 1.2 %, accounting for about 30% of the total alkaloids of Rauwolfia, therefore, people usually extract reserpine from Rauwolfia.

[0003] The main clinical effect of Ayimalin is anti-arrhythmia, and its content generally accounts for about 15% of the total alkaloids of Rauwolfia. Because there are alkaloids in Rauwolfia similar in structure to Ayimalin, they are isolated from Rauwolfia Ayi Malin is more difficult. The ex...