Chinese medicinal extractum and extraction process thereof

A technology of traditional Chinese medicine and extract, applied in the direction of ointment delivery, medical formula, plant raw materials, etc., can solve the problems of high toxicity, achieve strong antibacterial and bactericidal effects, short extraction time, and high yield

Inactive Publication Date: 2010-06-23
YIBIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although these drugs can effectively treat diseases, their toxicity is relative...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The three-flavor Chinese medicinal extract extraction process comprises the following steps:

[0017] (1) After the dried three medicinal materials are pulverized into fine powder respectively, take by weighing 40g of Sophora flavescens, 40g of Smilax miltiorrhiza, and 20g of white moss bark;

[0018] (2) Reflux extraction: 50% ethanol is the solvent, the time is 2h / time, and the extraction is performed twice; the extraction temperature is 80°C; the ratio of crude drug to ethanol reflux extraction is 1:20 (weight / volume);

[0019] (3) Combine 2 extracts, filter and concentrate under reduced pressure;

[0020] (4) Drying in vacuum at low temperature to obtain 26.79 g of Chinese medicinal extract, the MIC value is 0.78 mg / ml, and the MBC value is 0.78 mg / ml.

Embodiment 2

[0022] The three-flavor Chinese medicinal extract extraction process comprises the following steps:

[0023] (1) After the dried three medicinal materials are pulverized into fine powder respectively, take by weighing 40g of Sophora flavescens, 40g of Smilax miltiorrhiza, and 40g of white moss bark;

[0024] (2) Reflux extraction: 50% ethanol is the solvent, the time is 1h / time, and the extraction is performed twice; the extraction temperature is 80°C; the ratio of crude drug to ethanol reflux extraction is 1:10 (weight / volume);

[0025] (3) Combine 2 extracts, filter and concentrate under reduced pressure;

[0026] (4) Low-temperature vacuum drying to obtain 33.44 g of Chinese herbal extract, with MIC value of 1.56 mg / ml and MBC value of 3.12 mg / ml.

Embodiment 3

[0028] The three-flavor Chinese medicinal extract extraction process comprises the following steps:

[0029] (1) After the dried three medicinal materials are pulverized into fine powder respectively, take by weighing 40g of Sophora flavescens, 40g of Smilax miltiorrhiza, and 20g of white moss bark;

[0030] (2) Reflux extraction: 70% ethanol is the solvent, the time is 2h / time, and extraction is performed twice; the extraction temperature is 80° C.; the ratio of crude drug to ethanol reflux extraction is 1:10 (weight / volume);

[0031] (3) Combine 2 extracts, filter and concentrate under reduced pressure;

[0032] (4) Low-temperature vacuum drying to obtain 23.12 g of Chinese herbal extract, with MIC value of 0.195 mg / ml and MBC value of 0.39 mg / ml.

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Abstract

The invention relates to a Chinese medicinal extractum and an extraction process thereof. The Chinese medicinal extractum comprises the following components: lightyellow sophora root, glabrous greenbrier rhizome and cortex dictamni, wherein the mass ratio of the three components is 1-6:1-6:1-3. The preparation process is characterized by comprising the following steps: grinding the raw materials of lightyellow sophora root, glabrous greenbrier rhizome and cortex dictamni into fine powders; putting the fine powders into 50 to 95 percent ethanol to carry out reflux extraction for 1 to 3 hours at a temperature of between 75 and 95 DEG C, wherein the ratio of the raw materials to ethanol is 1:10-20 (weight/volume); carrying out filtration on the obtained product after extraction; putting the powders obtained by filtration into the ethanol repeatedly to extract 1 to 2 times again; after mixing the medical solution extracted repeatedly, carrying out pressure reduction and concentration on the mixture, and carrying out low-temperature vacuum drying on the obtained product to obtain the Chinese medicinal extractum. The process is simple, has short time consumption and high yield, and is convenient for the industrial production. The yield of the Chinese medicinal extractum is over 26 percent. Bacteriostasis test shows that the MIC value of the Chinese medicinal extractum to Candida albicans is 0.195mg/ml, the MBC value of the Chinese medicinal extractum to Candida albicans is 0.78mg/ml, and the Chinese medicinal extractum has obvious effect of inhibiting and killing Candida albicans.

Description

technical field [0001] The invention relates to a traditional Chinese medicinal extract and its extraction process, in particular to a traditional Chinese medicinal extract for treating candidiasis by extracting active ingredients from three traditional Chinese medicines and its preparation process. Background technique [0002] Candidiasis (Cyathula officinalis Kuan) is a fungal disease caused by Candida, especially Candida albicans. The original bacteria can not only invade the skin and mucous membranes, but also involve internal organs. Most candidiasis may be caused by endogenous or exogenous infection, and with the progress of modern medicine, the development of various organ transplants, cardiac surgery and various catheter technologies, leading to the onset of this disease rate showed a clear upward trend. At present, antifungal drugs such as nystatin, amphotericin B, ketoconazole, and itraconazole are mostly used for the treatment of candidiasis. Although these dr...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/06A61P31/10
Inventor 魏琴殷中琼严得华周黎军
Owner YIBIN UNIV
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