General flavone extract of hollyhock flower, preparation thereof and application

A technology of total flavonoids and hollyhock flowers is applied in the field of medicine and achieves the effects of large adsorption capacity, simple operation and high desorption rate

Inactive Publication Date: 2013-10-23
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are few reports on the Uyghur medicine marshmallow flower total flavonoids preparation for treating cough and asthma, detumescence, poliomyelitis, constipation, hemorrhoids, insomnia and forgetfulness

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 100 g of crushed and dried hollyhock flowers, use 50% ethanol as the extractant with a volume fraction of 15 times the volume of the medicinal material, soak for 12 hours, then heat to reflux for extraction, collect the extract, and recover the ethanol under reduced pressure to obtain a concentrated solution , the obtained concentrated solution was purified by using D101 macroporous resin, and the sample was adsorbed for 1.0 hour, then washed with water, the volume of water washing was 2BV, and the flow rate of water washing was 1BV / h, and then eluted with ethanol, and the volume fraction of ethanol used for elution was 50% , the elution volume is 3BV, the elution rate is 2BV / h,

[0021] The ethanol eluate was collected, concentrated, and vacuum-dried at 50°C to obtain a dry purified product. The yield of total flavonoids extract is 3.3%, and its total flavonoids content is 67.5% in terms of rutin by weight percentage, and its component content is: quercetin 25.6%,...

Embodiment 2

[0023] Take 100 g of crushed and dried hollyhock flowers, use 90% ethanol as the extractant with a volume fraction of 10 times the volume of the medicinal material, first soak for 12 hours, then heat to reflux for extraction, collect the extract, and recover the ethanol under reduced pressure to obtain a concentrated solution , the obtained concentrated solution was purified by using HP-400 macroporous resin, and the sample was adsorbed for 2.0 hours, then washed with water, the volume of water washing was 4BV, and the flow rate of water washing was 3BV / h, and then eluted with ethanol, the volume fraction of ethanol used for elution was 70%, the elution volume is 4BV, the elution speed is 4BV / h,

[0024] The ethanol eluate was collected, concentrated, and vacuum-dried at 50°C to obtain a dry purified product. The yield of the total flavonoids extract is 3.1%, and its total flavonoids content is 60.3% in terms of rutin by weight percentage. Ingredient balance.

Embodiment 3

[0026] Take 100 g of crushed and dried hollyhock flowers, use 0% ethanol as the extractant with a volume fraction of 20 times the volume of the medicinal material, first soak for 12 hours, then heat to reflux for extraction, collect the extract, and recover the ethanol under reduced pressure to obtain a concentrated solution , the obtained concentrated solution was purified by using AB-8 macroporous resin, and the sample was adsorbed for 1.0 hour, then washed with water, the volume of water washing was 3BV, and the flow rate of water washing was 2BV / h, and then eluted with ethanol, the volume fraction of ethanol used for elution was 60%, the elution volume is 2BV, the elution speed is 3BV / h,

[0027] The ethanol eluate was collected, concentrated, and vacuum-dried at 50°C to obtain a dry purified product. The yield of total flavonoid extract is 3.4%, and its total flavonoid content is 64.7% in terms of rutin by weight percentage, and its component content is: quercetin 22.6%, ...

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Abstract

The invention belongs to the technical field of medicaments and relates to a method for purifying the general flavone resin of hollyhock dried flower which is a Chinese herbal medicament in Uyghur. Extract obtained through the backflow extraction with ethanol and the purification of macroporous resin comprises 50 to 90 weight percent of general flavone, wherein the flavone comprises the following components in percentage by weight: 15.0 to 45.0 percent of quercetin, 5.0 to 20.0 percent of kaempferol, 3.0 to 18 percent of astragaloside and the balance of the other flavonoid components. The general flavone extract of the hollyhock flower of the invention is used for preparing the medicaments for treating cough and asthma, detumescence, poliomyelitis, constipation, hemorrhoids, insomnia and amnesia.

Description

Technical field: [0001] The invention relates to a method for purifying components of Uighur medicine, in particular to an extract of total flavonoids from hollyhock flowers, its preparation and application, and belongs to the technical field of medicine. Background technique: [0002] Hollyhock flower is the dried flower of Althaea rosea (L.) Gavan., a plant of Malvaceae, which is different from hollyhock flower. Picked in summer and dried in the sun. Irregular cylindrical or long ovate, 3 to 5 cm long, a few fragments with calyx. The flower color is mainly purple-red and light pink-white. The corolla has 5 petals or double petals, which are mostly bonded into a group. After being moistened with water, it is obovate. Tufts of dense down. There are many stamens, the filaments unite into a tube, and the anthers are yellow. Petals are white, flexible and thin, slightly brittle when dry. The gas is slightly fragrant, and the taste is light. The functions and indications a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P7/10A61P25/00A61P1/10A61P9/14A61P25/20A61P11/06A61P11/14A61K133/00
CPCY02A50/30
Inventor 段洪东王世潇
Owner QILU UNIV OF TECH
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