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Preparation process of inclusion compound of moldavica dragonhead volatile oil

A preparation process and volatile oil technology, applied in the field of preparation of volatile oil inclusion compounds of Uygur medicine, can solve the problems of inability to be effectively utilized, light sensitive, easy to decompose, etc., and achieve the effects of increased stability, increased solubility and broad development prospects.

Inactive Publication Date: 2012-07-11
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, as one of the main components, the volatile oil of fragrant green orchid has strong volatility, is sensitive to light, and is easy to decompose under strong light, so it cannot be effectively utilized.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] In a four-necked flask with 100ml of distilled water, add 6.00g of β-CD, stir and raise the temperature to make a saturated aqueous solution of β-CD; cool the saturated solution to 40°C, slowly add 1.00g of fennel volatile oil dropwise, and add After completion, mechanically stir at constant temperature for 1 hour, heat preservation is completed, suction filtration, the filter cake is washed three times with a small amount of petroleum ether (60-90°C) and distilled water, and dried to obtain 5.95g of clathrate volatile oil with a yield of 85%. .

Embodiment 2

[0015] Add 10.00g of β-CD to a four-neck flask filled with 100ml of distilled water, stir and heat up to make a saturated aqueous solution of β-CD; cool the saturated solution to 40°C, slowly add 1.00g of volatile oil of Cymbidium indigo, drop After the addition was completed, stir mechanically at a constant temperature for 1 hour. After the heat preservation was completed, suction filtration was carried out. The filter cake was washed three times with a small amount of petroleum ether (60-90° C.) and distilled water, and dried to obtain 8.95 g of the clathrate of the volatile oil of fennel, with a yield of 81 %.

Embodiment 3

[0017] Add 8.00g of β-CD to a four-necked flask filled with 100ml of distilled water, stir and raise the temperature to make a saturated aqueous solution of β-CD; cool the saturated solution to 40°C, slowly add 1.00g of volatile oil of Cinnamomum indigo, drop After the addition was completed, stir mechanically at a constant temperature for 1 hour. After the heat preservation was completed, suction filtration was carried out. The filter cake was washed three times with a small amount of petroleum ether (60-90° C.) and distilled water, and dried to obtain 8.10 g of clathrates of volatile oil of sweet green blue, with a yield of 90 %.

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PUM

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Abstract

The invention belongs to the technical field of medicine, which relates to a preparation process of an inclusion compound of moldavica dragonhead volatile oil. Releasable solid powder is generated by adopting the action of beta-CD and the moldavica dragonhead volatile oil, and the stability of the volatile oil is obviously increased. The invention adopts a beta-CD inclusion technique to include the moldavica dragonhead volatile oil, the stability of the moldavica dragonhead volatile oil is obviously increased, and chemical components are not changed after the moldavica dragonhead volatile oilis included. The solubility of the prepared inclusion compound is obviously increased, and the inclusion compound can be prepared into various medicament forms and has extensive market prospect.

Description

Technical field: [0001] The invention relates to a preparation method of the volatile oil inclusion compound of Uyghur medicine, in particular to a preparation method of the inclusion compound of the volatile oil and β-CD of orchid orchid. Background technique: [0002] Dracocephalum moldavica L. is an annual herb of the Labiatae genus Dracocephalum moldavica L., and it is called Badlandjibuya in Uyghur. It is one of the commonly used Uyghur medicines in Xinjiang. Its medicinal part is the dry aerial part, which has the effects of relieving exterior pain and relieving pain, clearing heat and cooling liver. Function, mainly used in the treatment of hypertension, coronary heart disease, angina pectoris, atherosclerosis, myocardial ischemia, hepatitis and other diseases. Prescriptions have been recorded in the Uighur classic medical books "Ali Kanon" with a history of more than 800 years, "Maikesan Aidevi" with a history of more than 500 years, "Isir Azamu" and "Maikesan Yikem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K47/48A61P9/12A61P9/10A61P1/16A61K47/69
Inventor 段洪东李晓萌
Owner QILU UNIV OF TECH