Hemostasis composition containing batroxobin and preparation method thereof

A thrombin-like and composition technology, applied in the field of hemostatic compositions and their preparation, can solve the problems of inability to cross-link fibrin, carrying zoonotic viruses and the like
CN101797378AInactive Publication Date: 2010-08-11BEIJING SAISHENG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING SAISHENG PHARMA
Publication Date
2010-08-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a novel hemostasis composition which comprises fibrinogen or hemaleucin, and batroxobin, wherein the ratio of the batroxobin to the fibrinogen or hemaleucin is 0.01:100IU:1mg. Because a clot formed by the batroxobin can not cause contraction, and the batroxobin can not cause crossimmunity reaction, the hemostasis composition can overcome multiple defects existing in hemostasis products containing thrombin or prothrombin.
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Description

technical field

[0001] The invention relates to a hemostatic composition and a preparation method thereof, more particularly to a hemostatic composition containing thrombin-like enzyme and a preparation method thereof. Background technique

[0002] The coagulation process of humans and animals includes the formation and cross-linking of fibrin, which includes the formation of fibrin monomers, polymerization and cross-linking of fibrin.

[0003] 1) Formation of fibrin monomer: Fibrinogen is synthesized by the liver and has two α chains (Aa), two β chains (Bβ), and two γ chains (γ2), namely three pairs of different polypeptide chains The constituent glycoproteins can be represented by (Aa, Bβ, γ)2. Under the action of thrombin, fibrinogen releases A and B small peptides to form fibrin monomers.

[0004] 2) Polymerization and cross-linking of fibrin monomers: Polymer clots formed by connecting soluble fibrin monomers through secondary bonds such as hydrogen bonds. Although blo...

Claims

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