Gamma secretase modulators

Abstract

In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

Description

gamma secretase modulator Related application reference This application claims the benefit of US Provisional Application No. 60 / 916,458, filed May 7, 2007. field of invention The present invention relates to certain heterocyclic compounds, which are used as gamma secretase modulators (including inhibitors, antagonists, etc.); pharmaceutical compositions containing said compounds; and using said compounds and compositions to treat various diseases Methods for the treatment of diseases including central nervous system disorders, such as neurodegenerative diseases, such as Alzheimer's disease; and other diseases involving amyloid deposition. They are particularly useful for reducing the production of amyloid beta (hereinafter referred to as Aβ), which is effective in the treatment of diseases caused by Aβ, such as Alzheimer's disease and Down's syndrome. Background of the invention Alzheimer's disease is a disease characterized by the degeneration and loss of neurons, as...

AI Technical Summary

Problems solved by technology

Currently, the treatment of Alzheimer's disease is limited to symptomatic therapy using a symptom-improving agent represented by an acetylcholinesterase inhibitor, and basic therapy for preventing the progression of the disease has not been developed

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