5-alkoxy-tetrazo[1,5-a]qualone derivative and pharmaceutically acceptable salt thereof serving as antidepressants

Abstract

The invention relates to novel 5-alkoxy-tetrazo[1,5-a]qualone compounds, which are represented by a general formula I, and an addition salt formed by the compound and pharmaceutically acceptable acid. The invention also relates to use of the compounds and the addition salt formed by the compounds and the pharmaceutically acceptable acid as antidepressants.

Description

technical field The present invention relates to 5-alkoxy-tetrazolo[1,5-a]quinolinone derivatives, their addition salts with pharmaceutically acceptable acids, their preparation methods and their use in the preparation of antidepressants and containing their pharmaceutical compositions. Background technique Depression is the main type of affective disorder (Mood Disorder), which is a syndrome characterized by significant and persistent low mood. With the fast-paced and mental and psychological pressure brought by the market economy, the incidence of depression has increased significantly. According to a survey by the World Psychiatric Association, the global incidence of depression is 4.2%, and it reaches 6.9% in China, and the number of patients with depression is increasing at an annual growth rate of 113%. According to statistics, the cost of absenteeism, loss of work ability, treatment and rehabilitation caused by patients with depression in my country reaches hundreds...

AI Technical Summary

Problems solved by technology

However, about 1 / 3 of the depressed patients in the world do not respond well to clinically used antidepressants, and the toxic side effects are obvious after long-term use of these antidepressants

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