Application of 7P peptide in preventing or treating pneumonia

A pneumonia and lung technology, applied in the field of medicine, can solve the problems of no observation of 7P and its derivatives pneumonia lesions symptoms, no 7P and its derivatives found, etc.

Inactive Publication Date: 2010-09-08
程云 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, unlike nephritis and liver injury, pneumonia, especially the pneumonia caused by the increase of TNFα, causes pulmonary inflammatory lesions through the pathway of TNFα increase, and it has not been found in the prior art that 7P and its derivatives can inhibit Increased TNFα in the lungs, and it was not observed that 7P and its derivatives can improve the symptoms of pneumonia lesions

Method used

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  • Application of 7P peptide in preventing or treating pneumonia
  • Application of 7P peptide in preventing or treating pneumonia
  • Application of 7P peptide in preventing or treating pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1. The protective effect of immune 7-peptide drugs on pneumonia in mice

[0042] 1. Experimental materials

[0043] 1.1 Animals:

[0044] Clean-grade ICR mice, weighing 18g-22g, male and female, were provided by the Experimental Animal Center of Nantong University (experimental animal production license: SCXK (Su) 2008-0010; experimental animal use license: SYXK (Su) 2007-- 0030).

[0045] 1.2 Drugs:

[0046] The peptide whose sequence is GQTYTSG (hereinafter referred to as "immune 7 peptide") is dissolved in physiological saline before use.

[0047] Positive control drug: dexamethasone injection, provided by Guizhou Huasheng Pharmaceutical Co., Ltd., batch number: 071017, specification: 5mg / ml / bottle.

[0048] 1.3 Drug preparation, dosage and grouping

[0049] Dexamethasone injection group (administration dose is 0.9mg / kg), immune 7 peptide drug high, medium and low dose groups were 250μg / kg, 125μg / kg, 62.5μg / kg, blank control group, model group were given...

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Abstract

The invention discloses application of hepatitis C virus immunogenic peptide 7P and a derivative thereof in preparing medicaments for preventing or treating pneumonia, in particular to application of the peptide or the derivative thereof in preparing medicaments of a 250 microgram/kg mouse dosage for preventing or treating the pneumonia.

Description

technical field [0001] The present invention belongs to the technical field of medicine, in particular, the present invention relates to the application of hepatitis C virus immunogenic peptide 7P and its derivatives in the preparation of medicines for preventing or treating pneumonia, especially to the preparation of the peptide or its derivatives Application of the drug in the prevention or treatment of pneumonia at a dose of 250 μg / kg in mice. Background technique [0002] The peptide whose sequence is GQTYTSG (abbreviated as 7P herein) is an immunogenic peptide originally designed according to hepatitis C virus. Peptide 7P and its derivatives. In addition, in PCT application WO / 2007 / 137456, the inventors also found that 7P and its derivatives can also be used for the prevention and treatment of liver damage, especially for the prevention or treatment of immune liver damage and hepatotoxic chemical substances. of liver damage. Afterwards, the inventors discovered that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61P11/00
Inventor 程云虞瑞鹤赵万洲陈平雁李伯安
Owner 程云
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