Magnetic phase-change microcapsule for performing thermal protection on normal structure in thermal physical therapy

Abstract

The invention discloses a magnetic phase-change microcapsule for performing thermal protection on a normal structure in thermal physical therapy. The magnetic phase-change microcapsule is a spherical microcapsule which is composed of a phase-change material (1), magnetic particles (2) and a liposome shell (3), and the mean diameter thereof is 1nm-1mm. In the invention, the phase-change material (1) is solid-liquid or / and liquid-solid phase-change material with high phase change heat and the phase change temperature at -10-0 DEG C or 38-100 DEG C according to different thermal physical therapeutic processes such as thermal therapy, cold therapy, cryosurgery or cold-heat alternating therapy and the like; the magnetic particles (2) are magnetic micro / nano-particles or magnetotactic bacteria;and a liposome is taken as a capsule carrier for lowering toxicity of the material and protecting an encapsulated material. The invention provides a safe and effective thermal protection material with novel concept. In the invention, the magnetic phase-change microcapsule can be gathered into a target organ with blood circulation under the action of an applied magnetic field; phase-change latent heat and low thermal conductivity of the phase-change material are adopted to carry out thermal protection on the normal structure; and the material is widely applied to thermal physical therapy, and the application method thereof is simple, feasible and reliable.

Description

technical field [0001] The invention relates to a magnetic phase-change microcapsule for thermal protection of normal tissues in thermal physical therapy, in particular to a magnetic phase-change microcapsule composed of magnetic particles, phase-change materials and liposome shells. Background technique [0002] Typical thermophysiotherapy includes tumor hyperthermia, cold therapy, cryosurgery and alternating cold and heat therapy, etc. Tumor hyperthermia refers to a treatment method that uses heating to increase the local temperature of the cancerous part of the human body, thereby eliminating cancer cells It has been more than 100 years since a case of soft tissue sarcoma confirmed by pathology was cured after erysipelas infection and high fever in 1886. The development of modern tumor hyperthermia biology has laid a basic biological foundation for corresponding clinical practice. Among the factors that affect the high efficacy of tumor hyperthermia, the most critical one...

AI Technical Summary

Problems solved by technology

Although these methods can play a certain role in protecting normal tissues, they are still far from achieving the desired results.

Poor tissue thermal conductivity, limited depth of surface thermal protection, limited thermal protection of normal tissue in the treatment of deep tumor diseases

The use of targeted therapy can improve the effect of tumor tissue, but it is inevitable to damage the normal tissue around the target area due to heat conduction.

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