Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Fructan consisting of 25 fructoses and 1 glucose

A technology of fructan and glucose, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, and pharmaceutical formulas, and can solve problems such as secondary failure, dosage increase, and chronic complications that cannot be effectively controlled

Inactive Publication Date: 2012-02-29
HUAZHONG UNIV OF SCI & TECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the chemical drugs currently used clinically to treat diabetes have serious adverse reactions, and long-term use needs to be increased and there is a possibility of secondary failure, especially the chronic complications cannot be effectively controlled

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fructan consisting of 25 fructoses and 1 glucose
  • Fructan consisting of 25 fructoses and 1 glucose
  • Fructan consisting of 25 fructoses and 1 glucose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] The preparation of the invented fructan: take 5kg of Hubei Ophiopogon japonicus tuber, crush it into raw medicinal material powder, add water to decoct 3 times, add 20 liters of water for the first time, add 20 liters of water for the second time, add 10 liters of water for the third time, and boil each time After 30 minutes, combine the water decoction; adjust the pH of the water decoction to 6 with phosphate buffer, add 25 g of papain with an activity of 12u / mg, enzymolyze it in a water bath at 45°C for 2 hours, then boil it immediately for 5 minutes, and put it under static conditions at 4°C. Put it in place for more than 12 hours, suction filter to remove the precipitate; put the filtrate into a dialysis bag with a molecular weight of 1000, dialyze with tap water for 1 day, then dialyze with distilled water for another 1 day, concentrate the polysaccharide solution in the bag to 1.5g / mL, add absolute ethanol to the volume of ethanol Fraction is 80%, 4 DEG C stand sti...

Embodiment 2

[0130] The preparation of the fructan capsule of the present invention: add 35 g of microcrystalline cellulose to 965 g of the fructan powder of the present invention, mix evenly, sieve, and dry to obtain the medicinal raw material of the drug capsule. The medicinal raw materials are filled into 2924 capsules, and each medicinal capsule containing 0.33g of the fructan of the present invention is prepared, which is equivalent to each capsule containing 2.68g of Hubei Ophiopogon japonicus medicinal material. Adults are advised to take the fructan capsules of the present invention once a day in the morning and evening, one capsule each time, for more than 4 weeks.

Embodiment 3

[0132] The preparation of the fructan tablet of the present invention: add 35 g of microcrystalline cellulose to 965 g of the fructan powder of the present invention, mix evenly, sieve, and dry to obtain the medicinal raw material of the pharmaceutical tablet. The medicinal raw material is dry-processed into granules and compressed into tablets to obtain 5848 pharmaceutical tablets of the fructan of the present invention, each containing 0.165 g of the fructan of the present invention, which is equivalent to 1.34 g of the Hubei Ophiopogon japonicus medicinal material contained in each capsule.

[0133] It is recommended that adults take the fructan tablet of the present invention twice a day, once in the morning and before dinner, 2 tablets each time, and take continuously for more than 4 weeks.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
Login to View More

Abstract

The invention provides a fructan consisting of 25 beta-D-fructoses and 1 alpha-D-glucose, and a method for preparing the fructan from Hubei dwarf lilyturf tuber serving as a raw material. The fructan has obvious effect of reducing blood sugar of mice with type 2 diabetes, simultaneously improves the sugar tolerance of the mice with the type 2 diabetes, and obviously enhances the expression of insulin receptor (InsR), insulin receptor substrate (IRS-1), protein kinase and phosphatidylinositol3-kinase (PI3-K) to further accelerate the glucose to be converted into glycogen and improve the activities of glucose-6-phosphate and glucose-6-phophatase so as to obvious reduce the insulin resistance.

Description

Background technique [0001] Diabetes mellitus (DM) is a chronic systemic frequently-occurring disease related to genetic factors and various environmental factors. It is a syndrome of sugar, fat and protein metabolism disorders caused by insufficient insulin secretion or utilization. Diabetes disease" category. The prevalence of diabetes in my country is increasing year by year, especially in type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), but there is no ideal drug for treatment at home and abroad. Most of the chemical drugs currently used clinically to treat diabetes have serious adverse reactions. Long-term use needs to be increased and there is a possibility of secondary failure, especially the chronic complications cannot be effectively controlled. Traditional Chinese medicine has the characteristics of being easy to accept, less toxic and side effects, and suitable for long-term control of diabetes. It has irreplaceable advantages in effectively preven...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/733A61P3/10
Inventor 陈家春陈祥洪白雪文莉方进波
Owner HUAZHONG UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com