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Bacillus Ling oral liquid and preparation method thereof

A technology of oral liquid and bacilli, which is applied in the direction of antibacterial drugs, pharmaceutical formulas, and medical preparations containing active ingredients, etc. It can solve the problems of prolonged medication time, drug residues, and high cost, and achieve simple process control and high bioavailability High, good efficacy

Inactive Publication Date: 2010-10-06
JIANGXI ZHONGCHENG MEDICINE GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the abuse of antibacterial drugs, the prevention of a large number of sub-therapeutic doses, the addition of drugs to feed, and the uncontrolled extension of drug use time have all led to the generation and spread of drug resistance in E. [1]
With the continuous emergence of drug-resistant strains, many antibacterial drugs will lose efficacy after 2 to 3 years of continuous use, and have the characteristics of high toxicity, high cost, and drug residues.

Method used

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  • Bacillus Ling oral liquid and preparation method thereof
  • Bacillus Ling oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. The main components of the bacillin oral liquid are composed, and are calculated in parts by weight. The raw materials are composed as follows: 250 parts of Coptis chinensis, 650 parts of Scutellaria baicalensis, 400 parts of gardenia, 200 parts of Andrographis paniculata, 200 parts of Pulsatilla radix, 150 parts of licorice;

[0032] 2. And prepare according to the following process steps and process parameters:

[0033] Mix 250 parts of Coptis chinensis, 650 parts of Scutellaria baicalensis, 400 parts of gardenia, 200 parts of Andrographis paniculata, 200 parts of Pulsatilla chinensis, 150 parts of licorice, and mix the 6 herbs evenly. Concentrated under pressure to the extract with a relative density of 1.15g / ml, add appropriate amount of auxiliary materials and 40% sucrose, stir well, add water to 800-2000 parts, let stand for 24 hours, make up water to the original number of parts, fill, and get .

[0034] The prepared bacillin oral liquid was mixed with drinking...

Embodiment 2

[0036] 1. The main components of the bacillin oral liquid are composed, and are calculated in parts by weight. The raw materials are composed as follows: 300 parts of Coptis chinensis, 600 parts of Scutellaria baicalensis, 450 parts of gardenia, 250 parts of Andrographis paniculata, 250 parts of Pulsatilla radix, 100 parts of licorice;

[0037] 2. And prepare according to the following process steps and process parameters:

[0038] Mix 300 parts of Coptis chinensis, 600 parts of Scutellaria baicalensis, 450 parts of gardenia, 250 parts of Andrographis paniculata, 250 parts of Pulsatilla chinensis, 100 parts of licorice, and 6 herbs, add water and decoct twice, combine the decoction, filter, and keep the temperature at 60 ° C. Concentrate under pressure to the extract with a relative density of 1.10g / ml, add appropriate amount of auxiliary materials and 30% sucrose, stir well, add water to 1000 parts, let stand for 24 hours, make up water to the original number of parts, fill, a...

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Abstract

The invention discloses a bacillus Ling oral liquid and a preparation method thereof. The bacillus Ling oral liquid is mainly prepared from the following raw material components by weight parts: 250-450 parts of rhizoma coptidis, 500-700 parts of baikal skullcap roots, 300-500 parts of gardenia, 200-400 parts of common andrographis herb, 150-300 parts of roots of Chinese pulsatilla and 50-200 parts of liquorice. The preparation method comprises the steps of: mixing the six medicines in uniformity, adding water and decocting for two times; filtering; maintaining the temperature at 55-65 DEG C; decompressing and concentrating into extractum with a relative density of 1.05-1.20g / ml; adding a proper amount of auxiliary materials and 25-40% of sucrose, and stirring in uniformity; adding water to be in 800-2000 parts; settling for 24 hours; adding enough water to be in the original part; and bottling to obtain the bacillus Ling oral liquid. The bacillus Ling oral liquid has the advantages of simple process control, high bioavailability, good effect, high efficacy and low cost.

Description

technical field [0001] The invention relates to the field of drugs for treating colibacillosis, in particular to bacillin oral liquid for treating colibacillosis in animals and a preparation method thereof. Background technique [0002] Colibacillosis is a bacterial infectious disease caused by Escherichia coli (E. At present, it has risen to be one of the most difficult diseases that endanger the poultry industry. Colibacillosis is mainly prevented by bacterin immunity, antibacterial drugs and Chinese herbal medicine. Among them, due to the complex serotypes, intestinal microbial antigens and antigenic determinants of bacterin immunity, there are differences in immune mechanisms, and breakthroughs have not been made in the prevention and treatment of the disease from the perspective of bacterins, and the immune effect is often inaccurate. Therefore, antibiotics are still the main means of prevention and treatment of the disease. However, the abuse of antibacterial drugs, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/00A61P31/04A61P1/12A61P11/00A61P1/00
Inventor 付仲襄付宁晨付宁静杨彦平
Owner JIANGXI ZHONGCHENG MEDICINE GROUP
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