The invention discloses healthcare five-cereal powder and a preparation method. The healthcare five-cereal powder comprises the following components in parts by mass: 30-50 parts of black soybeans, 10-20 parts of black rice, 10-20 parts of black sesame, 1-10 parts of black pumpkin seeds, 1-10 parts of gorgon euryale seeds, 1-10 parts of tartary buckwheat, 2-12 parts of common yam rhizome, 5-15 parts of walnut kernels, 1-5 parts of radix puerariae, 0.1-0.5 part of semen allii tuberosi, 0.1-0.5 part of abelmoschus esculentus, 1-8 parts of pinto beans, 2-6 parts of chestnuts, 5-15 parts of red dates, 0.1-0.3 part of lotus seeds and 0.1-0.5 part of Chinese angelica. The preparation method comprises the following steps: (1) raw material selection; (2) composition preparation; (3) low-temperature baking; (4) liquid nitrogen quick freezing; (5) raw material smashing; (6) raw material freeze-drying; and (7) sub-packaging. In the healthcare five-cereal powder, by making full use of the nutrition characteristics of the cereals and through scientific proportioning, the active ingredients are completely maintained, and the healthcare five-cereal powder is pure natural without additive and is green and healthy, adjusts the immunologic mechanism of human body and realizes the healthcare functions of adjusting and removing toxin, nourishing kidney and strengthening body, clearing heat and removing toxin, tonifying deficiency and replenishing essence, expelling stone and draining water, clearing urinary tract, nourishing kidney and moistening lung, tonifying liver and improving vision and the like.