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New compound structure and preparation method and application thereof

A technology of compounds and mixtures, applied in the field of preparation of anti-tumor drugs and treatment of tumors, which can solve problems such as neurotoxicity

Inactive Publication Date: 2010-11-17
天津天颐科苑科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although sophoridine has antitumor effects, it has certain neurotoxicity

Method used

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  • New compound structure and preparation method and application thereof
  • New compound structure and preparation method and application thereof
  • New compound structure and preparation method and application thereof

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Embodiment 1

Embodiment 2

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Abstract

The invention relates to a new compound with the structure of the formula (I) and a preparation method thereof, wherein R1, R2, R3 and R4 in the formula are defined in the specification. The invention also relates to a drug composite and a drug preparation containing the compound, a preparation method thereof and the application of the compound in preparing anti-tumour drug and treating tumour.

Description

technical field The present invention relates to a new compound, a pharmaceutical composition containing the new compound, a preparation method thereof, and an application of the new compound in preparing antitumor drugs and treating tumors. Background technique Malignant tumor is one of the three major "killers" threatening human health. According to statistics, since 2003, there are 16 million cancer cases and 10 million deaths worldwide every year. There are 1.6 million cancer cases and 1 million deaths in China every year, and the number is still increasing every year. Cancer prevention and treatment has a long way to go. At present, the means of cancer treatment mainly include chemotherapy, radiotherapy, surgery and biological methods. Chemotherapy and radiotherapy not only kill tumor cells but also damage normal cells, seriously affecting the survival and quality of life of patients. Therefore, finding high-efficiency and low-toxic tumor therapeutic drugs has become...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/16A61K31/4375A61P35/00G01N33/15G01N21/31
Inventor 刘培勋李欣孺陈毓杰洪阁马世堂徐阳禹洁龙伟
Owner 天津天颐科苑科技有限公司