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Novel application of rubus alceaefolius poir total alkaloid

A technology of Rubus vulgaris and total alkaloids is applied in the field of medicine to achieve the effects of good therapeutic effect, increasing content and reducing content

Inactive Publication Date: 2010-12-15
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on the use of total alkaloids of Rubus lata in the treatment of non-alcoholic fatty liver disease

Method used

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  • Novel application of rubus alceaefolius poir total alkaloid
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  • Novel application of rubus alceaefolius poir total alkaloid

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Embodiment 1 The preparation of the total alkaloids of Rubus japonicus of the present invention

[0027] Take by weighing 200g of Rubus thick leaves and place it in a 2000ml round-bottomed flask, add 1200ml85% ethanol solution (solid-to-liquid ratio 1:6) and place it in an electronic constant temperature electric heating mantle at 80°C for reflux 3 times, each time for 30 minutes, combine the extracts, The ethanol is recovered to obtain a concentrated solution, which is then dried to obtain the total alkaloids of Rubus japonicus.

[0028] The quality standard of the total alkaloids of Rubus ruba is using berberine hydrochloride as a reference, using the acid dye colorimetric method, and measuring at a wavelength of 415nm. , greater than 95% w / w.

[0029] In addition to the above-mentioned extraction method, it can also be extracted by the method reported in the literature at present, such as: Hong Zhenfeng, et al., Determination of the content of total alkaloids in the...

Embodiment 2

[0030] The preparation of embodiment 2 pharmaceutical tablet of the present invention

[0031] Take the total alkaloids of Rubus ruba prepared in Example 1, add auxiliary materials for tablets, granulate and compress into tablets to obtain tablets.

[0032] Prove beneficial effect of the present invention by pharmacodynamic test below.

experiment example 1

[0033] Experimental example 1 Experiment of treating non-alcoholic fatty liver with the total alkaloids of the drug Rubus of the present invention

[0034] 1) Animal grouping, modeling and administration

[0035] 60 SD rats were randomly divided into 6 groups, 10 in each group, and each group was divided into half male and half male, that is, normal group, fatty liver model group, Yishanfu polyene phosphatidylcholine (polyene phosphatidylcholine, PPC group). ) control group and 3 treatment groups of high, medium and low doses of total alkaloids of Rubus rubus (TARAP). The other 2 rats were incorporated into the model group as a sample to check the modeling effect.

[0036] Except for the normal group, the rats in other groups were fed with high-fat diet instead of basic diet for 12 weeks. Ratio of high-fat feed: basic feed 87.3%, lard 10%, cholesterol 2%, pig bile salt 0.7%. At the 10th week of modeling, one female rat and one male rat were randomly selected from the model ...

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Abstract

The invention provides application of rubus alceaefolius poir total alkaloid to preparing a medicament for treating non-alcoholic fatty liver and a pharmaceutical composition for treating the non-alcoholic fatty liver. The rubus alceaefolius poir total alkaloid is an effective component extracted from the root of a traditional Chinese medicine of rubus alceaefolius poir, has remarkable improving or reversing effect on the fatty degeneration of liver cells and the lipid accumulation index in a high-fat diet animal model, can reduce the contents of serum total cholesterol and the low-density lipoprotein cholesterol and improve the contents of high-density ipoprotein cholesterol. The invention shows that the rubus alceaefolius poir total alkaloid has better treatment function on the non-alcoholic fatty liver, in particular has more excellent pharmaceutical effect on the simple fatty liver and provides a new pharmaceutical selection for clinical application.

Description

technical field [0001] The invention relates to a new application of the total alkaloids of Rubus japonicus, in particular to the application in the preparation of medicines for treating non-alcoholic fatty liver, belonging to the field of medicines. Background technique [0002] Rubus alceaefolius Poir., RAP, is the root and leaf of Rubus alceaefolius Poir., a plant of the family Rosaceae, also known as big leaf snake paoir, big rag thorn, tiger pao, tiger palm poir, Jiuyue pao, etc. It is rich in medicinal resources, mainly distributed in Jiangsu, Jiangxi, Fujian, Taiwan, Hunan, Guangdong, Guangxi, Guizhou, Yunnan and other places in China. It grows in sunny hillsides at an altitude of 500-2000m, in miscellaneous forests in valleys or in swampy bushes and roads. Among the nearby rocks, its roots and leaves are used as medicine, sweet and light in taste, and has the effects of promoting blood circulation and removing blood stasis, clearing heat and stopping bleeding, etc. I...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P1/16A61K125/00A61K127/00
Inventor 洪振丰赵锦燕郑海音周建衡徐伟
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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