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Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity

A compound, heteroaryl technology, applied in the field of indole compounds with aryl or heteroaryl groups having biological activity of 1-phosphate-sphingosine (S1P) receptor

Inactive Publication Date: 2010-12-15
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although some of the compounds reported in the above patents are indoles, it appears that indole compounds have not been reported as ligands for sphingosine receptors or have sphingosine agonist or antagonist activity

Method used

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  • Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity
  • Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity
  • Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity

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Embodiment Construction

[0038] It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed. As used herein, a singular form also includes a plural form unless specifically stated otherwise. As used herein, "or" means "and / or" unless stated otherwise. Furthermore, the use of the term "comprising" as well as other forms such as "comprises" and "comprises" is not limiting. The section headings used herein are for organizational purposes only and should not be construed as limitations on the subject matter described.

[0039]Unless specific definitions are given, the laboratory methods and techniques of analytical chemistry, synthetic organic and inorganic chemistry described herein and the terminology used in connection therewith are those known in the art. Standard chemical symbols are used interchangeably with the full names denoted by these symbols. Thus, for exampl...

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Abstract

The invention provides well-defined aryl and / or heteroaryl substituted indoles that are useful as sphingosine-1 -phosphate agonists or antagonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of sphingosine-1 -phosphate receptors.

Description

[0001] inventor [0002] R.L. Beard, Piao Haiqing and J.E. Donnellow [0003] cross reference [0004] This application claims priority to US Provisional Application Serial No. 60 / 974,511, filed September 24, 2007, which is incorporated herein by reference in its entirety. technical field [0005] The present invention generally relates to aryl- and heteroaryl-substituted indoles and their use as agonists or antagonists, for example as agonists or antagonists of sphingosine-1-phosphate receptors . In particular the present invention relates to the use of these compounds and pharmaceutical compositions for the treatment of diseases associated with modulation of sphingosine-1-phosphate receptors. Background technique [0006] Sphingosine is a compound having the chemical structure shown in the following general formula, wherein Y 1 is hydrogen. It is known that various sphingolipids composed of sphingosine are widely distributed in the living body, including on the cell m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/42C07D401/06C07D401/12C07D409/06C07D413/06C07D413/14C07D417/14C07D513/04A61K31/404
CPCC07D401/12C07D413/14C07D417/14C07D401/06C07D513/04C07D209/42C07D409/06C07D413/06A61P17/02A61P25/04A61P27/02A61P27/06A61P43/00A61P9/00
Inventor R·L·比尔德袁海卿J·E·唐奈罗
Owner ALLERGAN INC