Substituted cyclohexenones

Abstract

The present invention relates to a method of preparation of an optically active cyclohexenone derivative of Formula (I) and wherein R1 and R2 are organic residues.

Description

technical field The present invention relates to the field of organic synthesis, more particularly to a method for preparing optically active cyclohexenone derivatives of general formula (I), where R 1 and R 2 defined below. Background technique Optically active cyclohexenone derivatives are useful intermediates or building blocks for the synthesis of various more complex compounds, such as steroids or macrocyclic ketones, which are known as certain C 14 、C 15 or C 16 Useful musky fragrance like 3-methylcycloenone. Despite this fact, to the best of our knowledge, the prior art only reports very few methods for the preparation of optically active cyclohexenone derivatives from achiral diketones or aldol adducts. In patent applications WO 2005 / 077875 and WO 2007010483, the use of chiral amino alkoxides and the use of achiral diketones or achiral aldol adducts as starting materials are described. In another document (see C. Agami et al. in Bulletin de la Société Ch...

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Problems solved by technology

However, as will be shown further below, the methods described in the examples are not effective when used in the matrix of the present invention

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