Method for preparing ginkgodipyidamolum injection
A technology of Damo injection and Ginkgo biloba, which is applied in the field of preparation of Ginkgo Damo injection, can solve problems such as medication safety risks and poor product quality stability, and achieve the goals of improving quality stability, improving drug effectiveness, and reducing safety risks Effect
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Embodiment 1
[0028] 1. Extract Ginkgo biloba extract: Extract Ginkgo biloba with 6 times the weight of purified water, extract twice, reflux for 2 hours each time, filter, combine the filtrates and concentrate to 1 / 3 of the original volume; stir the concentrate Cool and let it stand, then take the supernatant, filter, absorb the filtrate through D101 macroporous resin, elute with ethanol, concentrate the eluate until it has no alcohol smell, then add purified water 2 times the weight of ginkgo leaves, stir and cool, then let it stand place, get the supernatant, filter, concentrate the filtrate to collect the paste, vacuum-dry until the water content is below 6% (weight), and pulverize;
[0029] 2. Refined ginkgo leaf extract: add 8 times the weight of 90% (volume) ethanol to the ginkgo leaf extract obtained in step 1, stir until dissolved, concentrate to no alcohol after centrifugation, then add 10 times concentrated medicine Liquid volume of purified water, stirred and cooled, left stands...
Embodiment 2
[0044] 1, extract Ginkgo biloba extract: same as Example 1;
[0045] 2. Refined Ginkgo biloba extract: Add 12 times the weight of 90% (volume) ethanol to the Ginkgo biloba extract obtained in step 1, stir until dissolved, concentrate to no alcohol after centrifugation, then add 10 times concentrated medicine Liquid volume of purified water, stirred and cooled, left standstill, the supernatant was taken, centrifuged and concentrated to collect the paste, dried in vacuum until the water content was below 6% (weight), and pulverized;
[0046] 3. Prepare ginkgo leaf extract: add purified water with 10 times the amount of the extract to the ginkgo leaf extract, heat to mix evenly, add dipyridamole at 0.5% by weight of the ginkgo leaf extract, adjust the pH value to 4.51, Continue heating to boiling, reflux for 1 hour, stop heating, cool to room temperature, and retest the pH to 4.46; then take the supernatant and filter it with a 0.22 μm filter membrane frame, and the filtrate is u...
Embodiment 3
[0053] 1, extract Ginkgo biloba extract: same as Example 1;
[0054] 2, refining Ginkgo biloba extract: use dehydrated alcohol, all the other steps are identical with embodiment 1;
[0055] 3. Preparation of ginkgo leaf extract: add purified water of 10 times the amount of the extract to the ginkgo leaf extract, heat to mix evenly, add dipyridamole of 2% by weight of the ginkgo leaf extract, adjust the pH value to 4.78, Continue heating to boiling, reflux for 0.5 hours, stop heating, cool to room temperature, and retest the pH to 4.65; then take the supernatant and filter it with a 0.22 μm filter membrane frame, and the filtrate is ultrafiltered with a 100,000 Dalton filter membrane, Pump the above-mentioned ultra-filtered liquid into a sterilization tank for heat sterilization. When the temperature rises to 115°C, start timing, and sterilize at 115±2°C for 40 minutes. After cooling, the ginkgo leaf extract is prepared for use;
[0056] 4. Preparation of ginkgo damole injecti...
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