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Anti-tumor epothilone oral liquid

A technology of epothilone and oral liquid, applied in the direction of antineoplastic drugs, drug delivery, organic active ingredients, etc., can solve the shortage of anticancer drugs and other problems, and achieve the effect of high efficiency and simple purification process

Inactive Publication Date: 2011-02-09
李桂云
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is a shortage of effective anticancer drugs in the world, even for paclitaxel, there are still many shortcomings

Method used

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  • Anti-tumor epothilone oral liquid
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  • Anti-tumor epothilone oral liquid

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Experimental program
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Embodiment approach

[0026] 1. Isolation and purification of myxobacteria

[0027] I could have purchased a strain of sorangium cellulosum, but I decided to grow my own because myxobacteria are a class of Gram-negative prokaryotes that produce abundant secondary metabolites and are commonly found in animal feces and rich in organic matter It can also grow on decaying materials such as rotten wood, bark, lichen and herbivore's excrement in the soil or alkaline environment.

[0028] (1) Soil sample collection

[0029] Soil samples for the isolation of myxobacteria were collected from soils in less-trampled forests and under bamboo forests. After the sample is collected, air-dry it naturally, store it at room temperature, and use it as soon as possible. The sample should not be stored for more than 1 month.

[0030] (2) The formation of fruiting bodies induced by yellow goat dung pellets

[0031] Put the soil sample in a small Erlenmeyer flask, bathe in water at 58°C for 10 minutes to kill most of...

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Abstract

The invention relates to an anti-tumor epothilone oral liquid. EpothiloneA-epothilonel are combined in different ways to generate different epothilone liquid mixtures; and the liquid mixtures are used as oral liquids since the epothilones are effective when being orally taken.

Description

technical field [0001] The invention belongs to anti-tumor natural products and is a macrolide compound. Background technique [0002] In 1988, Hofle first screened and found epothilone from a strain of myxobacterium cellulosum (sorangium cellulosum) in African soil. In 1995, Bollag et al. found that epothilone A and B are a class of It is an anti-tumor compound with a novel structure, which has the property of promoting tubulin polymerization similar to paclitaxel. [0003] Epothilone has a strong cytotoxic activity on cells, among which Epothilone B has a stronger effect. According to previous experiments, Epothilone can induce the polymerization of tubulin to form microtubules under the condition of low concentration and the absence of GTP and tubulin. The mechanism of action Similar to Taxol, it binds to the Taxol binding site of microtubules, increases the stability of microtubules by increasing the strength of interaction between protofilaments, prevents the formation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P35/00A61K31/427A61K9/08
Inventor 李桂云
Owner 李桂云
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