Chip automatic loading device of microarray chip scanner

Abstract

The invention relates to a chip automatic loading device of a microarray chip scanner, which is characterized by comprising a clamping box, a clamping box inlet and outlet device and a positioning bin, wherein a microarray chip is arranged in the clamping box, and when the microarray chip scanner is in a non-working state, the clamping box is placed outside a scanning platform of the microarray chip scanner; the clamping box inlet and outlet device is connected with the positioning bin, and can be used for automatically loading the clamping box in the positioning bin; and the positioning bin is arranged above the scanning platform of the microarray chip scanner, and used for positioning the working surface of the microarray chip in the clamping box. The invention not only can effectively protect the microarray chip from being damaged and polluted, but also has the characteristics of simple structure and low cost, thereby being capable of being widely applied to various microarray chipscanners.

Description

technical field [0001] The invention relates to an automatic chip loading device, in particular to an automatic chip loading device for a microarray chip scanner. Background technique [0002] Microarray is to first label the messenger RNA of biological samples from cells, tissues and other sources with fluorescent dyes to obtain cDNA, and then use a glass microarray chip containing thousands of genes to hybridize with cDNA, fluorescently labeled cDNA molecules and The matching DNA sequence on the chip undergoes a hybridization reaction, making the spots on the chip present a fluorescent signal, and the intensity of the fluorescent signal is in positive phase with the abundance of gene expression. Microarray technology acts like a biological microprocessor, enabling rapid and quantitative analysis of gene expression profiles, patient genotypes, drug metabolism, disease occurrence and progression, etc. on a genome scale. Microarray chip detection technology emerged with the ...

AI Technical Summary

Problems solved by technology

[0004] At present, there are some microarray chip scanners that can automatically load chips on the market. Most of the chip automatic loading devices are complex in structure and expensive. Some chip damage or vibration cracks often occur during the automatic chip loading process or scanning process. Phenomenon

The slide loading mechanism of the invention patent US 4159875 has two slide storage boxes, one is used to store slides to be inspected, and the other is used to store inspected chips. The volume is relatively large, and the chips can only be loaded sequentially from bottom to top. Take out or store; the structure of the slide box is complicated, and the barcode is on the slide box, and the barcode of the microarray chip currently used is mostly marked on the chip

Some instruments for microscopic observation also use slide automatic loading devices. For example, the microscope slide automatic loading frame mentioned in the invention patent US 6847481 B1 includes three parts: slide frame, XY motion platform and slide selection arm. Slides are loaded from one storage frame to the microscope operating table, and unloaded to another storage frame after work is completed. This device can complete the automatic loading and unloading of slides, but the slides are exposed during loading, unloading and working without any protection. , easy to be contaminated or damaged; in addition, because it is used for microscope observation, the focus of the microscope can be used to make the image clear during the observation process, so the positioning of the working surface of the slide is not considered, and it is not suitable for automatic loading of microarray chips

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