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Enzymatically synthesized triglyceride type fish oil soft capsules and preparation method thereof

An enzymatic synthesis, triglyceride technology, applied in the direction of capsule delivery, non-active ingredients of polymer compounds, drug combination, etc., can solve the problems of unqualified capsule products, rising to 2.5 or even higher, etc.

Active Publication Date: 2013-02-20
河北康睿达脂质有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the water-containing rubber is in contact with the diglycerides and monoglycerides in the high-concentration EPA+DHA and is very active, the prepared capsules will cause the acid value to rise from less than 1 to 2.5 or even higher due to the emulsification and water absorption and hydrolysis of the contents, which exceeds the national standard. The quality control standards for polyene fish oil products in the industry, as well as the standard for finished product acid value less than 1 required in European, American, and British pharmaceutical end products, lead to unqualified capsule products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] a. Sol process: take 250 g / 1000 grains of distilled water into a container, use steam to heat to 80°C, add 98g / 1000 grains of glycerin and 244 g / 1000 grains of vegetable glue, then control the temperature at 70°C, and the vacuum degree is 0.05Mpa. Stir and defoam for 15 minutes; control the temperature at 75°C, stir and dissolve for 15 minutes; then control the temperature at 65°C, vacuum degree 0.09Mpa, defoaming and concentration for 20 minutes; finally at 55°C, filter and release the glue through a 120 mesh filter bag. The liquid moisture is 40%, and the glue is kept at 45℃.

[0027] b. Ingredients process: take 510 g / 1000 capsules of enzymatically synthesized fish oil, its triglyceride 65%, diglyceride 28%, monoglyceride 1.5%, ethyl ester 5.5%; filter through 120 mesh, add natural vitamin E oil 2g / 1000 grains, stir for 40 minutes to mix evenly, set aside.

[0028] c. Qualitative pill pressing: control the temperature of the pill room at 20%, the relative humidity at 45%...

Embodiment 2

[0034] a. Sol process: take 400 g / 1000 grains of distilled water into a container, use steam to heat to 80°C, add 150g / 1000 grains of glycerin and 244g / 1000 grains of animal glue, then control the temperature at 80°C, vacuum degree 0.05Mpa, and stir Degas for 25 minutes; control the temperature at 80℃, stir and dissolve for 20 minutes; then control the temperature at 75℃, vacuum degree of 0.09Mpa, degassing and concentration for 25 minutes; finally at 70℃, filter and release the glue through a 120 mesh filter bag, and the resulting glue The water content is 40%, and the glue is kept at 45℃.

[0035] b. Batching process: Take 700 g / 1000 capsules of enzymatically synthesized fish oil, 75% triglycerides, 19% diglycerides, 1.5% monoglycerides, and 6% ethyl esters; filter through 120 mesh and add natural vitamin E oil 4g / 1000 grains, stir for 50 minutes to mix evenly, set aside.

[0036] c. Qualitative pill pressing: control the temperature of the pill room at 20%, the relative humidit...

Embodiment 3

[0042] a. Sol process: take 580 g / 1000 grains of distilled water into the container, use steam to heat to 80°C, add 200g / 1000 grains of glycerin and 244 g / 1000 collagen glue, then control the temperature at 80°C, and the vacuum degree is 0.05Mpa , Stir and defoam for 30 minutes; control the temperature at 85℃, stir and dissolve for 30 minutes; then control the temperature at 80℃, the vacuum degree of 0.09Mpa, degas and concentrate for 30 minutes; finally at 80℃, filter and release the glue through a 120 mesh filter bag, the result The water content of the glue is 40%, and the glue is kept at 45℃.

[0043] b. Ingredients process: take 510 g / 1000 capsules of enzymatically synthesized fish oil, 80% triglycerides, 15% diglycerides, 2.5% monoglycerides, 2.5% ethyl esters; filter through 120 meshes and add natural vitamin E oil 5g / 1000 grains, stir for 70 minutes to make it evenly mixed and set aside.

[0044] c. Qualitative pill pressing: control the temperature of the pill room at 20%...

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PUM

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Abstract

The invention discloses a method for preparing enzymatically synthesized triglyceride type fish oil soft capsules. 1,000 soft capsules comprise the following raw materials by weight: 499 to 1,200g of enzymatically synthesized fish oil, 1 to 5g of natural vitamin E oil, 244g of gelatin, 100 to 220g of glycerin and 244 to 590g of distilled water. The product prepared by the method has stable quality, an acid value of less than 1, a peroxide value of less than 5 percent and an anisidine value of less than 20 percent, and can meet the requirement of food shelf life.

Description

Technical field [0001] The invention relates to a fish oil soft capsule and a preparation method thereof, in particular to an enzymatically synthesizing high-concentration triglyceride type fish oil soft capsule and a preparation method thereof. Background technique [0002] In the synthesis of fish oil drugs rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), because triglyceride-type oils are easily absorbed by the human body and have no side effects, it is composed of ethyl fish oil, Triglyceride fish oil synthesized by transesterification of glycerol and lipase has been listed as a raw material for the treatment of cardiovascular and cerebrovascular diseases and nutritional supplements in the European and American Pharmacopoeia. Since the enzymatic transesterification process is to separate the ethanol from the ethyl ester fish oil through a biological reaction, it is combined into the same amount of glycerin to form a new glycerin with more than 60% triglycer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K35/60A61K47/42A61P3/02A61P9/10
Inventor 苑洪德孙秀云苑海鹏苑海祥
Owner 河北康睿达脂质有限公司