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New application of choline compound medicament combination

A technology of compounds and uses, which is applied in the field of new uses of choline compounds in combination, and can solve the problems of drug dependence, hazards, side effects, etc.

Inactive Publication Date: 2011-05-18
北京赛德维康医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, there are two main categories of drugs for the treatment of pain: one is non-steroidal antipyretic analgesic anti-inflammatory drugs; the other

Method used

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  • New application of choline compound medicament combination
  • New application of choline compound medicament combination
  • New application of choline compound medicament combination

Examples

Experimental program
Comparison scheme
Effect test

Example

[0082] Test Example 1

[0083] Analgesic effect of compound of general formula (I) combined with non-steroidal antipyretic analgesics in acetic acid writhing test

[0084] In the research of the present invention, it was found that the compound of general formula (I) and non-steroidal antipyretic analgesics have the activity of treating peripheral pain.

[0085] The test results are shown in Figure 5 , 6 , 7. It shows the results of writhing pain in mice after intraperitoneal injection of acetic acid. Mice were given dihydrocholine citrate in the tail vein 105 minutes after the administration, aspirin 5mg / Kg was given in the tail vein, 15 minutes after the administration, 0.6% acetic acid solution 0.1ml / 10g was injected into the mouse's abdominal cavity, and the administration of acetic acid was recorded. The number of writhing times in the next 20 minutes. The relationship between dihydrocholine citrate and different doses of aspirin combined with analgesic dose. ( figure 1 )...

Example

[0086] Test Example 2

[0087] The experimental results of dihydrocholine citrate combined with aspirin to shorten the analgesic latency of aspirin.

[0088] The test results are shown in figure 1 , 8 . It shows the results of writhing pain in mice after intraperitoneal injection of acetic acid. Aspirin was administered to the tail vein at 5 mg / Kg, and 0.6% acetic acid solution 0.1 ml / 10 g was injected into the abdominal cavity of the mice at different time points after the administration. The number of writhing times in the mice within 20 minutes after the acetic acid was recorded. Give the mouse tail vein 8mg / Kg of dihydrocholine citrate (no analgesic effect) 105 minutes after administration, give aspirin 5mg / Kg to the tail vein, 15 minutes after administration, intraperitoneal injection of 0.6 % Acetic acid solution 0.1ml / 10g, record the number of writhing times of mice within 20 minutes after acetic acid is given.

Example

[0089] Test Example 3

[0090] The test results are shown in figure 1 . It shows the results of writhing pain in mice after intraperitoneal injection of acetic acid. Aspirin 5mg / Kg was administered to the tail vein. At different time points after the administration, the mice were given dihydrocholine citrate via the tail vein. 120 minutes after the administration, the mice were injected with a 0.6% acetic acid solution 0.1ml / 10g into the abdominal cavity of the mice. The number of writhing times in mice within 20 minutes after acetic acid. The experimental results of the combined application of dihydrocholine citrate and aspirin to prolong the analgesic time of aspirin.

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PUM

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Abstract

The invention relates to new application of choline compound medicament combination, in particular to application of combination of a compound shown as a formula (I) and a nonsteroidal antipyretic analgesic to preparation of medicaments for treating and/or preventing pain, particularly central pain or peripheral pain. In the formula, R1 is selected from a hydroxyl group, an acid group of pharmaceutically acceptable inorganic acid or an acid group of pharmaceutically acceptable organic acid; and R2 is selected from hydrogen, an acyl group with one carbon atom to six carbon atoms and a sulphonyl group. The invention also provides a medicinal composition and a medicament box product on the basis of the new application. According to the invention, the compound shown as the formula (I) effectively reduces the effective analgesic dose of the nonsteroidal antipyretic analgesic, shortens the latent period of the nonsteroidal antipyretic analgesic and prolongs analgesic duration of the nonsteroidal antipyretic analgesic.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new application of choline compounds in combination, in particular to a new application of choline compounds and non-steroidal antipyretic and analgesic joint applications, in particular to choline compounds and non-steroidal The combined application of antipyretic and analgesic drugs can synergistically enhance the analgesic effect, especially significantly shorten the incubation period of non-steroidal antipyretic and analgesic drugs, and more importantly, significantly prolong the time course of their analgesic effects, and significantly reduce the choline Novel use of the compound and its non-steroidal antipyretic analgesic drug in an effective analgesic dose of the pharmaceutical composition. Background technique [0002] At present, there are two main categories of drugs for the treatment of pain: one is non-steroidal antipyretic analgesic anti-inflammatory drugs; the othe...

Claims

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Application Information

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IPC IPC(8): A61K31/205A61K31/14A61K31/616A61P25/04A61P29/00
Inventor 汪海石永平王汝欢王金达于海涛赵想弟
Owner 北京赛德维康医药研究院
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