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A pharmaceutical composition for treating and/or preventing inflammatory pain and its application

A technology for inflammatory pain and composition, which is applied in the directions of drug combination, non-central analgesic, medical preparation containing active ingredients, etc., can solve the problems of enhancing the analgesic effect of tetrahydropalmatine and the like

Active Publication Date: 2019-04-16
北京赛德维康医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether choline can enhance the analgesic effect of tetrahydropalmatine has not been reported in the literature

Method used

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  • A pharmaceutical composition for treating and/or preventing inflammatory pain and its application
  • A pharmaceutical composition for treating and/or preventing inflammatory pain and its application
  • A pharmaceutical composition for treating and/or preventing inflammatory pain and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: the analgesic effect of dihydrocholine citrate in acetic acid writhing experiment

[0028] Mice were injected with 0, 8, 16 and 32 mg / kg of dihydrocholine citrate into the tail vein, and 0.6% acetic acid solution 0.1ml / 10g was injected intraperitoneally after 120 minutes of administration, and the torque of the mice within 20 minutes after the injection of acetic acid was recorded. The body count was used to evaluate the analgesic effect of the drug. Data are expressed as mean±SEM, n=10, compared with saline group: * p** pfigure 1 shown. It shows that dihydrocholine citrate can dose-dependently reduce the number of writhing in mice induced by acetic acid.

Embodiment 2

[0029] Embodiment 2: Analgesic effect of tetrahydropalmatine in acetic acid writhing experiment

[0030] Mice were intraperitoneally injected with Tetrahydropalmatine 0, 0.5, 1.0, 2.0 and 4.0 mg / kg, and 0.6% acetic acid solution 0.1ml / 10g was injected intraperitoneally after administration for 15 minutes, and the writhing of mice within 20 minutes after acetic acid injection was recorded The number of times used to evaluate the analgesic effect of the drug. The data are expressed as mean±SEM, n=10, compared with the saline group: *p figure 2 shown. Show that tetrahydropalmatine can dose-dependently reduce the number of mice writhing caused by acetic acid.

Embodiment 3

[0031] Example 3: Analgesic effect of combined application of different doses of dihydrocholine citrate and different doses of tetrahydropalmatine in acetic acid writhing test

[0032]Mice were injected with dihydrocholine citrate 0, 0.125, 0.25, 0.50, 1.00, 2.00 and 8.00 mg / kg into the tail vein respectively, and intraperitoneally injected with tetrahydropalmatine 0, 0.015, 0.03, 0.0625, 0.125, 0.25 and 105 minutes after administration. 1.00mg / kg, intraperitoneally inject 0.6% acetic acid solution 0.1ml / 10g in mice 15 minutes after administration, and record the number of writhing times of mice within 20 minutes after acetic acid injection to evaluate the analgesic effect of the drug. Data are expressed as mean±SEM, n=10, compared with saline group: * p** p image 3 A, 3B shown. It shows that the combined application of choline and tetrahydropalmatine can synergistically reduce the number of writhing in mice caused by acetic acid.

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PUM

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Abstract

The invention discloses a medicinal composition for treating and / or preventing inflammatory pain, and belongs to the technical field of medicine. The medicinal composition comprises at least one effective-dose compound for treatment and / or prevention in a formula 1, effective-dose tetrahydropalmatine or tetrahydropalmatine salt acceptable in pharmacy for treatment and / or prevention and an optional carrier or excipient acceptable in pharmacy. The invention further discloses application of the medicinal composition in preparation of medicine for treating and / or preventing the inflammatory pain. Acetic acid twisting experimental model researches of mice show that the compounds in the formula 1 can effectively lower the effective analgesic dose of the tetrahydropalmatine, occurrence of an adverse reaction of the tetrahydropalmatine is reduced or avoided, and combined application of the compounds in the formula 1 and the tetrahydropalmatine has the synergistic analgesic effect on the inflammatory pain.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition for treating and / or preventing inflammatory pain and its application. Background technique [0002] About 8% of people in the world suffer from persistent or chronic periodic pain, and pain seriously affects quality of life. At present, the drugs used clinically to treat pain are mainly opioid analgesics and non-steroidal anti-inflammatory drugs. The former can cause adverse reactions such as tolerance, dependence, and respiratory depression, while the latter can cause gastrointestinal reactions and coagulation disorders. Adverse reactions such as allergic reactions and allergic reactions limit their clinical application. Therefore, finding an analgesic drug or pharmaceutical composition that is safe, effective, and less adverse reactions has important clinical application value. [0003] Pain control has a complex network due to complex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P29/00A61K31/14
CPCA61K31/14A61K31/4375A61K2300/00
Inventor 汪海王汝欢石永平
Owner 北京赛德维康医药研究院
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