A compound drug sustained-release preparation containing dezocine and lidoine and its preparation method

A sustained-release preparation, the technology of dezocine, applied in the field of medicine, can solve the problems of reducing the frequency of dosing, poor bioavailability of lidocaine, etc., and achieve the effect of relieving pain and stabilizing the drug release rate
CN110101660BActive Publication Date: 2020-05-15TIANJIN CITY THIRD CENT HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN CITY THIRD CENT HOSPITAL
Publication Date
2020-05-15

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Abstract

The invention provides a compound medicine sustained-release preparation containing dezocine and lidocaine and a preparation method thereof. The compound medicine sustained-release preparation is prepared from, by weight, 1-10 parts of dezocine, 1-10 parts of lidocaine, 1-10 parts of a polylactic acid-hydroxyacetic acid block copolymer, 1-10 parts of a dissolution aiding additive, 1-10 parts of anosmotic pressure regulator, 0.1-0.5 part of a pH value stabilizer, 1-5 parts of a wetting agent, 1-10 parts of a freeze-dried powder protectant, 10-50 parts of an organic solvent and 100-1000 parts of water for injection. Compared with an existing injection reagent, the compound drug sustained-release preparation containing dezocine and lidocaine is encapsulated in a biocompatible high-molecularpolymer to form an oil-in-water-in-oil structure, a medicine sustained-release effect can be obtained, the medicine release speed is stable, the stable blood concentration can be maintained for 8h ormore after single-time administration, the pain of a patient can be effectively relieved, and the compound drug sustained-release preparation can be used for analgesia of the patient after surgery.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition for anesthesia and analgesic injection and a preparation method thereof, in particular to a compound drug slow-release preparation containing dezocine and lidocaine and a preparation method thereof. Background technique

[0002] Lidocaine (English name lidocaine) is an amide local anesthetic mainly used for infiltration anesthesia, epidural anesthesia, topical anesthesia (including mucosal anesthesia during thoracoscopic examination or abdominal surgery) and nerve conduction block . Because oral absorption is good, but the first-pass effect of the liver can make 70% of the drug be metabolized, and the blood concentration is low, so it is not suitable for oral administration. After the drug is injected intravenously, the tissue distribution is fast and wide, and the blood-brain barrier can be passed through, and the blood drug concentration drops rapid...

Claims

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