Preparation method of hydrogel patch substrate with gradient drug concentration
A technology of drug concentration and hydrogel, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problem of high initial investment.
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[0029] Example 1
[0030] S1. Prepare a solution of sodium alginate (sodium alginate, item number S100126) with a concentration of 1%, and add dry micron-sized hydroxyapatite powder (0.0137g hydroxyapatite per 10ml of polysaccharide solution) and stir it evenly, and it is milky white The suspension is poured into a cylindrical mold of the required shape, and the mold is placed in a constant temperature and humidity box at 25°C;
[0031] S2. In the mold, add the freshly prepared gluconolactone solution with the molar ratio of calcium ions in the calcium salt of 4:5, and stir evenly.
[0032] S3. Put it in a centrifuge with a temperature controlled at 25°C, centrifuge for 40 minutes at a centrifugal speed of 4500r / min, and let it stand to get a hydrogel.
[0033] S4. Soak the hydrogel in 25ug / ml methylene blue for 24 hours to complete the drug gradient loading.
Example Embodiment
[0034] Example 2
[0035] S1. Prepare a solution of sodium alginate (sodium alginate, item number S100126) with a concentration of 5%, add dry nano-scale calcium carbonate powder (0.0274g calcium carbonate per 10ml polysaccharide solution), stir evenly, and pour into the required shape In the star mold;
[0036] S2. In the mold, add a freshly dissolved gluconolactone solution with a molar ratio of calcium ions in the calcium salt of 4:5, and stir evenly.
[0037] S3. Put it in a centrifuge, centrifuge for 15 minutes at a centrifugal speed of 2500r / min, and let it stand to get a hydrogel.
[0038] S4. Soak the hydrogel in 2 mg / ml colchicine for 18 hours to complete the drug gradient loading.
Example Embodiment
[0039] Example 3
[0040] S1. Prepare 3% sodium carboxymethylcellulose (sodium carboxymethylcellulose, item number C104979) natural polysaccharide solution, add dry nano-sized hydroxyapatite powder (add 0.0274g hydroxyl group per 10ml of polysaccharide solution Apatite) Stir evenly and pour it into a rectangular parallelepiped mold of the required shape;
[0041] S2. In the mold, add a freshly dissolved gluconolactone solution with a molar ratio of calcium ions in the calcium salt of 4:5, and stir evenly.
[0042] S3. Put it in a centrifuge, centrifuge for 30 minutes at a centrifugal speed of 2500r / min, and let it stand to get a hydrogel.
[0043] S4. Soak the hydrogel in 2 mg / ml sodium sulfadiazine for 36 hours to complete the drug gradient loading.
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