Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Memantine hydrochloride slow release-donepezil quick release compound capsule

A technology of donepezil hydrochloride and memantine hydrochloride, applied in the field of memantine hydrochloride sustained-release-donepezil immediate-release compound capsules and its preparation, can solve the problems of inability to reach donepezil, increase the burden of accompanying staff, and difficulty in ensuring patient compliance, etc.

Inactive Publication Date: 2017-05-31
ZHONGSHUAI PHARMA SCI & TECH CO LTD
View PDF3 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Most Alzheimer-type dementia patients are characterized by cognitive decline and dysphagia. If donepezil hydrochloride and memantine hydrochloride are taken once a day and memantine hydrochloride twice a day, the frequency and dosage of the medication are high, and it is difficult to ensure patient compliance sex, and increases the burden on the accompanying staff
[0007] In the prior art, there are also reports on the use of memantine hydrochloride and donepezil hydrochloride as compound preparations. For example, Chinese patent 2015106475920 describes a memantine hydrochloride sustained-release-donepezil quick-release compound capsule. 85%+ requirement, and a 24-hour sustained release requirement for the memantine hydrochloride portion

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Memantine hydrochloride slow release-donepezil quick release compound capsule
  • Memantine hydrochloride slow release-donepezil quick release compound capsule
  • Memantine hydrochloride slow release-donepezil quick release compound capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] The preparation method of memantine hydrochloride sustained-release-donepezil quick-release compound capsule comprises the following steps:

[0080] Step 1: Preparation of memantine hydrochloride sustained-release pellets

[0081] (1) Preparation of drug-containing pellets:

[0082] The drug-containing pellets include the following raw materials in parts by weight: 62 parts of blank ball cores, 20 parts of memantine hydrochloride, 10 parts of povidone, and 8 parts of talcum powder;

[0083] Add the binder into 95% ethanol under stirring, add the memantine hydrochloride and the lubricant in turn after the dissolution is complete, stir evenly to obtain the drug solution, and spray the drug solution on the blank pills On the core, after drying, the drug-containing pellets are obtained;

[0084] (2) Preparation of isolated pellets:

[0085] The drug-containing pellets include the following raw materials in parts by weight: 92 parts of drug-containing pellets, 3 parts of ...

Embodiment 2

[0096] The preparation method of memantine hydrochloride sustained-release-donepezil quick-release compound capsule comprises the following steps:

[0097] Step 1: Preparation of memantine hydrochloride sustained-release pellets

[0098] (1) Preparation of drug-containing pellets:

[0099] The drug-containing pellets include the following raw materials in parts by weight: 60 parts of blank core, 20 parts of memantine hydrochloride, 11 parts of povidone, and 10 parts of talcum powder;

[0100] Add the binder into 95% ethanol under stirring, add the memantine hydrochloride and the lubricant in turn after the dissolution is complete, stir evenly to obtain the drug solution, and spray the drug solution on the blank pills On the core, after drying, the drug-containing pellets are obtained;

[0101] (2) Preparation of isolated pellets:

[0102] The drug-containing pellets include the following raw materials in parts by weight: 98 parts of drug-containing pellets, 5 parts of hydro...

Embodiment 3

[0113] The preparation method of memantine hydrochloride sustained-release-donepezil quick-release compound capsule comprises the following steps:

[0114] Step 1: Preparation of memantine hydrochloride sustained-release pellets

[0115] (1) Preparation of drug-containing pellets:

[0116] The drug-containing pellets include the following raw materials in parts by weight: 53 parts of blank ball cores, 25 parts of memantine hydrochloride, 15 parts of povidone, and 10 parts of talcum powder;

[0117] Add the binder into 95% ethanol under stirring, add the memantine hydrochloride and the lubricant in turn after the dissolution is complete, stir evenly to obtain the drug solution, and spray the drug solution on the blank pills On the core, after drying, the drug-containing pellets are obtained;

[0118] (2) Preparation of isolated pellets:

[0119] The drug-containing pellets include the following raw materials in parts by weight: 88 parts of drug-containing pellets, 2 parts of...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a memantine hydrochloride slow release-donepezil quick release compound capsule. The compound capsule is prepared by jointly filling a capsule with memantine hydrochloride slow release pellets and donepezil quick release granules; the memantine hydrochloride slow release pellets are prepared by using medicinal empty pellet cores as original cores, dissolving memantine hydrochloride serving as main drug and proper excipients to form coating liquid, spraying the coating liquid to the bottom of a fluidized bed to form a drug-containing layer and sequentially coating the fluidized bed with an isolating layer and a slow release layer from inside to outside; the donepezil quick release granules are formed by subjecting donepezil hydrochloride serving as main drug and proper excipients to wet-process granulation, and the slow release pellets and quick release granules are filled into one same capsule according to a certain proportion of the main drug.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and discloses a pharmaceutical composition for treating moderate to severe Alzheimer's type senile dementia, in particular to a memantine hydrochloride slow-release-donepezil quick-release compound capsule and a preparation method thereof . Background technique [0002] Memantine hydrochloride is a non-competitive N-methyl-D-aspartic acid (NMDA) antagonist with moderate affinity, acting on the glutamine system in the brain. In the brains of Alzheimer's patients, neurofibrillary disorganization and degeneration occurred in the pyramidal cells of the cortical and subcortical pathways, which were reported to use glutamate as an excitatory transmitter. These neurons are damaged, and loss of function can lead to Alzheimer's disease; but if the function is too strong, it will produce excitotoxicity, cause neuron death, and cause various neurodegenerative diseases, so regulate the degeneratio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/62A61K31/445A61P25/28A61P25/16A61K31/13
CPCA61K9/5084A61K9/0002A61K9/5078A61K31/13A61K31/445A61K2300/00
Inventor 马丽董永生孙卫东余艳玲
Owner ZHONGSHUAI PHARMA SCI & TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products